F
IPR051877

Centriole and Basal Body Structural Protein
AI

InterPro entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Short nameCentriole_BasalBody_StrucProt
AI

Description

AI-generatedUnreviewed
This family of proteins is involved in the structural organization and biogenesis of microtubule-associated complexes. Members of this family play a crucial role in cytoskeletal organization, particularly in the formation and cohesion of centrioles and basal bodies, which are key components of the centrosome and cilia. They act as scaffolding proteins during early centriole biogenesis and are essential for the recruitment of various centriole satellite proteins and centriole-centriole cohesion during interphase. Some members are also implicated in meiosis and spermatogenesis, with additional functions such as regulating the nuclear localization of certain transcription factors. The presence of coiled-coil domains suggests that these proteins can form homodimers, which are important for their interaction with microtubules.
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