IPR052420
Espin and Espin-like domain-containing protein AI
InterPro entry
This entry contains information that has been generated using an AI language model. Please exercise discretion when interpreting the information provided.
Short name | Espin/Espin-like AI |
Description
AI-generatedUnreviewed
This family of proteins includes multifunctional actin-bundling proteins that are essential for the organization and dynamics of actin filament-rich structures. They play a pivotal role in the formation and maintenance of stereocilia in inner ear hair cells, which are crucial for hearing. Members of this family are involved in the assembly and stabilization of parallel actin bundles within these cellular protrusions and are necessary for the proper elongation of actin filaments. Additionally, they contribute to the regulation of stereocilia length and diameter, as well as the formation of the characteristic staircase pattern. Some family members are known to bind actin monomers through their WH2 domains, facilitating the assembly of actin bundles, while others bind to actin without promoting cross-linking.
Contributing Member Database Entry
- PANTHER:PTHR24153
Representative structure
5et1: Crystal structure of Myo3b-ARB1 in complex with Espin1-AR