D
IPR054337

Outer membrane cytochrome MtrC/MtrF-like, domains II/IV

InterPro entry
Short nameMtrc-MtrF_dom_II/IV
Overlapping
homologous
superfamilies
 

Description

This entry represents domains II and IV found in decaheme cytochrome c component MtrC from the MtrCAB complex and its homologues MtrF (which is part of the MtrFDE complex) and OmcA. In Shewanella oneidensis, these proteins are located at the bacterial cell surface at the termini of trans-outer-membrane electron transfer conduits and allow the utilization of extracellular mineral forms of iron and manganese as respiratory electron acceptors
[1, 2]
. MtrC/MtrF/OmcA consist of four domains: domain I and III contain seven antiparallel beta-strands in an extended Greek key topology; domains II and IV each bind five tightly packed hemes covalently attached to the Cys residues of the five CXXCH motifs in each domain and form the central core, flanked by domains I (
IPR054334
) and III (
IPR054355
)
[1, 2]
.

References

1.Structure of a bacterial cell surface decaheme electron conduit. Clarke TA, Edwards MJ, Gates AJ, Hall A, White GF, Bradley J, Reardon CL, Shi L, Beliaev AS, Marshall MJ, Wang Z, Watmough NJ, Fredrickson JK, Zachara JM, Butt JN, Richardson DJ. Proc. Natl. Acad. Sci. U.S.A. 108, 9384-9, (2011). View articlePMID: 21606337

2.Characterization of the decaheme c-type cytochrome OmcA in solution and on hematite surfaces by small angle x-ray scattering and neutron reflectometry. Johs A, Shi L, Droubay T, Ankner JF, Liang L. Biophys J 98, 3035-43, (2010). PMID: 20550916

Further reading

3. Crystal structures of photosynthetic reaction center and high-potential iron-sulfur protein from Thermochromatium tepidum: thermostability and electron transfer. Nogi T, Fathir I, Kobayashi M, Nozawa T, Miki K. Proc. Natl. Acad. Sci. U.S.A. 97, 13561-6, (2000). View articlePMID: 11095707

4. Structural basis of the drastically increased initial electron transfer rate in the reaction center from a Rhodopseudomonas viridis mutant described at 2.00-A resolution. Lancaster CR, Bibikova MV, Sabatino P, Oesterhelt D, Michel H. J. Biol. Chem. 275, 39364-8, (2000). View articlePMID: 11005826

5. The primary and three-dimensional structures of a nine-haem cytochrome c from Desulfovibrio desulfuricans ATCC 27774 reveal a new member of the Hmc family. Matias PM, Coelho R, Pereira IA, Coelho AV, Thompson AW, Sieker LC, Gall JL, Carrondo MA. Structure 7, 119-30, (1999). View articlePMID: 10368280

6. Three-dimensional structure of the nonaheme cytochrome c from Desulfovibrio desulfuricans Essex in the Fe(III) state at 1.89 A resolution. Umhau S, Fritz G, Diederichs K, Breed J, Welte W, Kroneck PM. Biochemistry 40, 1308-16, (2001). View articlePMID: 11170457

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