D
IPR055129

YEATS domain

InterPro entry
Short nameYEATS_dom
Overlapping
homologous
superfamilies
 
YEATS superfamily (IPR038704)

Description

This domain is found in the YEATS family, named after `YNK7', `ENL', `AF-9', and `TFIIF small subunit'. It folds into a β-sandwich with a C2-like topology
[3, 4]
. YEATS domain is an acetyllysine-binding domain that binds strongly to histone H3K9 acetylation and, to a lesser extent, H3K27 and H3K18 acetylation. This domain utilises a serine-lined aromatic 'sandwiching' cage for acetyllysine readout
[3, 4]
.

This family is named after YEATS (Yaf9, ENL, AF9, Taf14, and Sas5), an evolutionarily conserved module present in 4 proteins (ENL, AF9, GAS41, and YEATS2) in humans and 3 proteins (Sas5, Taf14, and Yaf9) in yeast. These proteins are found in major chromatin-remodeling and histone acetyl-transferase (HAT) complexes and implicated in regulation of chromatin structure, histone acetylation and deposition, gene transcription and DNA damage response. The YEATS domain, which as previously shown is found in a number of chromatin-associated proteins, has recently been shown to have the capacity to bind histone lysine acetylation
[1]
. The ability of the YEATS domains of human AF9 and yeast Taf14 to recognise the histone mark H3K9ac, have shown that these proteins are members of the family of acetyllysine readers
[2]
.

References

1.Structural Insights into Histone Crotonyl-Lysine Recognition by the AF9 YEATS Domain. Zhang Q, Zeng L, Zhao C, Ju Y, Konuma T, Zhou MM. Structure 24, 1606-12, (2016). View articlePMID: 27545619

2.Association of Taf14 with acetylated histone H3 directs gene transcription and the DNA damage response. Shanle EK, Andrews FH, Meriesh H, McDaniel SL, Dronamraju R, DiFiore JV, Jha D, Wozniak GG, Bridgers JB, Kerschner JL, Krajewski K, Martin GM, Morrison AJ, Kutateladze TG, Strahl BD. Genes Dev 29, 1795-800, (2015). PMID: 26341557

3.GAS41 promotes H2A.Z deposition through recognition of the N terminus of histone H3 by the YEATS domain. Kikuchi M, Takase S, Konuma T, Noritsugu K, Sekine S, Ikegami T, Ito A, Umehara T. Proc Natl Acad Sci U S A 120, e2304103120, (2023). View articlePMID: 37844223

4.AF9 YEATS domain links histone acetylation to DOT1L-mediated H3K79 methylation. Li Y, Wen H, Xi Y, Tanaka K, Wang H, Peng D, Ren Y, Jin Q, Dent SY, Li W, Li H, Shi X. Cell 159, 558-71, (2014). View articlePMID: 25417107

Further reading

5. YEATS Domain-A Histone Acylation Reader in Health and Disease. Zhao D, Li Y, Xiong X, Chen Z, Li H. J Mol Biol 429, 1994-2002, (2017). PMID: 28300602

6. Identification of the YEATS domain of GAS41 as a pH-dependent reader of histone succinylation. Wang Y, Jin J, Chung MWH, Feng L, Sun H, Hao Q. Proc Natl Acad Sci U S A 115, 2365-2370, (2018). PMID: 29463709

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