D
IPR055164

EDR1/CTR1/ARMC3-like, peptidase-like domain

InterPro entry
Short nameEDR1/CTR1/ARMC3-like_pept-like

Description

This entry represents a peptidase-like domain mainly found in plant proteins, including serine/threonine-protein kinases EDR1 and CTR1 from Arabidopsis thaliana. EDR1 regulates disease resistance and ethylene-induced senescence, and is also involved in stress response signaling and cell death regulation
[2, 5]
. CTR1 acts as a negative regulator in the ethylene response pathway
[1]
. It phosphorylates the cytosolic C-terminal domain of EIN2, preventing the signaling in the absence of ethylene
[3]
.

This entry also includes proteins from animals, such as ARMC3, which is essential for male fertility and sperm motility. During spermatogenesis, promotes the autophagic degradation of excessive ribosomes, providing energy resources for mitochondria and thus ensuring sperm flagellar motility
[4]
.

References

1.CTR1, a negative regulator of the ethylene response pathway in Arabidopsis, encodes a member of the raf family of protein kinases. Kieber JJ, Rothenberg M, Roman G, Feldmann KA, Ecker JR. Cell 72, 427-41, (1993). View articlePMID: 8431946

2.Regulation of plant disease resistance, stress responses, cell death, and ethylene signaling in Arabidopsis by the EDR1 protein kinase. Tang D, Christiansen KM, Innes RW. Plant Physiol 138, 1018-26, (2005). PMID: 15894742

3.CTR1 phosphorylates the central regulator EIN2 to control ethylene hormone signaling from the ER membrane to the nucleus in Arabidopsis. Ju C, Yoon GM, Shemansky JM, Lin DY, Ying ZI, Chang J, Garrett WM, Kessenbrock M, Groth G, Tucker ML, Cooper B, Kieber JJ, Chang C. Proc Natl Acad Sci U S A 109, 19486-91, (2012). View articlePMID: 23132950

4.Autophagic elimination of ribosomes during spermiogenesis provides energy for flagellar motility. Lei Y, Zhang X, Xu Q, Liu S, Li C, Jiang H, Lin H, Kong E, Liu J, Qi S, Li H, Xu W, Lu K. Dev Cell 56, 2313-2328.e7, (2021). View articlePMID: 34428398

5.Arabidopsis ENHANCED DISEASE RESISTANCE 1 is required for pathogen-induced expression of plant defensins in nonhost resistance, and acts through interference of MYC2-mediated repressor function. Hiruma K, Nishiuchi T, Kato T, Bednarek P, Okuno T, Schulze-Lefert P, Takano Y. Plant J 67, 980-92, (2011). View articlePMID: 21605210

Cross References

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