G3DSA:1.10.4020.10

DNA breaking-rejoining enzymes

CATH-Gene3D entry
Member databaseCATH-Gene3D
CATH-Gene3D typehomologous superfamily

Description
Imported from IPR038269

A number of C2H2-zinc finger proteins contain a highly conserved N-terminal motif termed the SCAN (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) domain. The SCAN domain has been shown to be able to mediate homo- and hetero-oligomerisation
[6]
. These proteins can either activate or repress transcription, although isolated recombinant SCAN domains do not modulate significantly the transcription
[3, 2]
. In addition to these zinc finger transcription factors, an isolated SCAN domain without adjacent zinc finger motifs has been identified in some proteins
[4, 1]
. It has been noted that the SCAN domain resembles a domain-swapped version of the C-terminal domain of the HIV capsid protein
[5]
.

The SCAN domain is enriched in hydrophobic and negatively charged residues with a L-X(6)-L motif at its core. This core is flanked by A, E, L, M, H and C residues that are frequently found in α-helices
[2]
. Predictions of the secondary structure of the domain suggest the presence of at least three α-helices that are separated from one another by short looped regions bounded by proline residues
[6]
. It has been shown to be a selective oligomerization domain that mediates homotypic and heterotypic interactions between SCAN box containing proteins
[1, 6]
.

References
Imported from IPR038269

1.The SCAN domain mediates selective oligomerization. Schumacher C, Wang H, Honer C, Ding W, Koehn J, Lawrence Q, Coulis CM, Wang LL, Ballinger D, Bowen BR, Wagner S. J. Biol. Chem. 275, 17173-9, (2000). View articlePMID: 10747874

2.Isolation and characterization of a novel zinc-finger protein with transcription repressor activity. Williams AJ, Khachigian LM, Shows T, Collins T. J. Biol. Chem. 270, 22143-52, (1995). View articlePMID: 7673192

3.Repression of transcriptional activity at a distance by the evolutionarily conserved KRAB domain present in a subfamily of zinc finger proteins. Pengue G, Calabro V, Bartoli PC, Pagliuca A, Lania L. Nucleic Acids Res. 22, 2908-14, (1994). View articlePMID: 8065901

4.An adipogenic cofactor bound by the differentiation domain of PPARgamma. Castillo G, Brun RP, Rosenfield JK, Hauser S, Park CW, Troy AE, Wright ME, Spiegelman BM. EMBO J. 18, 3676-87, (1999). View articlePMID: 10393183

5.Mammalian SCAN domain dimer is a domain-swapped homolog of the HIV capsid C-terminal domain. Ivanov D, Stone JR, Maki JL, Collins T, Wagner G. Mol. Cell 17, 137-43, (2005). View articlePMID: 15629724

6.The zinc finger-associated SCAN box is a conserved oligomerization domain. Williams AJ, Blacklow SC, Collins T. Mol. Cell. Biol. 19, 8526-35, (1999). View articlePMID: 10567577

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