Member database | CATH-Gene3D |
CATH-Gene3D type | homologous superfamily |
Description Imported from IPR012292
* Haemoglobin (Hb): tetramer of two alpha and two beta chains, although embryonic and foetal forms can substitute the alpha or beta chain for ones with higher oxygen affinity, such as gamma, delta, epsilon or zeta chains. Hb transports oxygen from lungs to other tissues in vertebrates
* Myoglobin (Mb): monomeric protein responsible for oxygen storage in vertebrate muscle
* Neuroglobin: a myoglobin-like haemprotein expressed in vertebrate brain and retina, where it is involved in neuroprotection from damage due to hypoxia or ischemia
* Cytoglobin: an oxygen sensor expressed in multiple tissues. Related to neuroglobin
* Erythrocruorin: highly cooperative extracellular respiratory proteins found in annelids and arthropods that are assembled from as many as 180 subunit into hexagonal bilayers
* Leghaemoglobin (legHb or symbiotic Hb): occurs in the root nodules of leguminous plants, where it facilitates the diffusion of oxygen to symbiotic bacteriods in order to promote nitrogen fixation.
* Non-symbiotic haemoglobin (NsHb): occurs in non-leguminous plants, and can be over-expressed in stressed plants
* Flavohaemoglobins (FHb): chimeric, with an N-terminal globin domain and a C-terminal ferredoxin reductase-like NAD/FAD-binding domain. FHb provides protection against nitric oxide via its C-terminal domain, which transfers electrons to haem in the globin
* Globin-coupled sensors: chimeric, with an N-terminal myoglobin-like domain and a C-terminal domain that resembles the cytoplasmic signalling domain of bacterial chemoreceptors. They bind oxygen, and act to initiate an aerotactic response or regulate gene expression
* Protoglobin: a single domain globin found in archaea that is related to the N-terminal domain of globin-coupled sensors
* Truncated 2/2 globin: lack the first helix, giving them a 2-over-2 instead of the canonical 3-over-3 α-helical sandwich fold. Can be divided into three main groups (I, II and II) based on structural features
* Anaerobic nitrite reductase: phytoglobin that reduces nitrite to nitric oxide (NO) under anoxic conditions
References Imported from IPR012292
1.Ancestral hemoglobins in Archaea. Freitas TA, Hou S, Dioum EM, Saito JA, Newhouse J, Gonzalez G, Gilles-Gonzalez MA, Alam M. Proc. Natl. Acad. Sci. U.S.A. 101, 6675-80, (2004). View articlePMID: 15096613
2.Human brain neuroglobin structure reveals a distinct mode of controlling oxygen affinity. Pesce A, Dewilde S, Nardini M, Moens L, Ascenzi P, Hankeln T, Burmester T, Bolognesi M. Structure 11, 1087-95, (2003). View articlePMID: 12962627
3.Structural and functional properties of hemoglobins from unicellular organisms as revealed by resonance Raman spectroscopy. Egawa T, Yeh SR. J. Inorg. Biochem. 99, 72-96, (2005). View articlePMID: 15598493
4.Sequential analysis of alpha- and beta-globin gene expression during erythropoietic differentiation from primate embryonic stem cells. Umeda K, Heike T, Nakata-Hizume M, Niwa A, Arai M, Shinoda G, Ma F, Suemori H, Luo HY, Chui DH, Torii R, Shibuya M, Nakatsuji N, Nakahata T. Stem Cells 24, 2627-36, (2006). View articlePMID: 16888280
5.Functional properties of neuroglobin and cytoglobin. Insights into the ancestral physiological roles of globins. Fago A, Hundahl C, Malte H, Weber RE. IUBMB Life 56, 689-96, (2004). PMID: 15804833
6.Myoglobin: an essential hemoprotein in striated muscle. Ordway GA, Garry DJ. J. Exp. Biol. 207, 3441-6, (2004). View articlePMID: 15339940
7.Protein structure in the truncated (2/2) hemoglobin family. Pesce A, Nardini M, Milani M, Bolognesi M. IUBMB Life 59, 535-41, (2007). View articlePMID: 17701548
8.Plant hemoglobins: what we know six decades after their discovery. Garrocho-Villegas V, Gopalasubramaniam SK, Arredondo-Peter R. Gene 398, 78-85, (2007). View articlePMID: 17540516
9.Flavohemoglobin, a globin with a peroxidase-like catalytic site. Mukai M, Mills CE, Poole RK, Yeh SR. J. Biol. Chem. 276, 7272-7, (2001). View articlePMID: 11092893
10.Globin-coupled sensors: a class of heme-containing sensors in Archaea and Bacteria. Hou S, Freitas T, Larsen RW, Piatibratov M, Sivozhelezov V, Yamamoto A, Meleshkevitch EA, Zimmer M, Ordal GW, Alam M. Proc. Natl. Acad. Sci. U.S.A. 98, 9353-8, (2001). View articlePMID: 11481493
11.Globin-coupled sensors, protoglobins, and the last universal common ancestor. Freitas TA, Saito JA, Hou S, Alam M. J. Inorg. Biochem. 99, 23-33, (2005). View articlePMID: 15598488
12.A phylogenomic profile of globins. Vinogradov SN, Hoogewijs D, Bailly X, Arredondo-Peter R, Gough J, Dewilde S, Moens L, Vanfleteren JR. BMC Evol. Biol. 6, 31, (2006). View articlePMID: 16600051
13.A model of globin evolution. Vinogradov SN, Hoogewijs D, Bailly X, Mizuguchi K, Dewilde S, Moens L, Vanfleteren JR. Gene 398, 132-42, (2007). View articlePMID: 17540514
14.Microbial globins. Wu G, Wainwright LM, Poole RK. Adv. Microb. Physiol. 47, 255-310, (2003). View articlePMID: 14560666
15.Low resolution crystal structure of Arenicola erythrocruorin: influence of coiled coils on the architecture of a megadalton respiratory protein. Royer WE Jr, Omartian MN, Knapp JE. J. Mol. Biol. 365, 226-36, (2007). View articlePMID: 17084861
16.Plant and cyanobacterial hemoglobins reduce nitrite to nitric oxide under anoxic conditions. Sturms R, DiSpirito AA, Hargrove MS. Biochemistry 50, 3873-8, (2011). View articlePMID: 21495624