Member database | CATH-Gene3D |
CATH-Gene3D type | homologous superfamily |
Description Imported from IPR036361
* Vertebrate scaffold attachment factors A and B (SAF-A/B). These two proteins are heterogeneous nuclear ribonucleoproteins (hnRNPs) that bind to AT-rich chromosomal region. It has been proposed that they couple RNA metabolism to nuclear organisation
* Mammalian Acinus, a protein which induces apoptotic chromatin condensation after cleavage by caspase-3
* Eukaryotic proteins of the PIAS (protein inhibitor of activated STAT) family. These proteins interact with phosphorylated STAT dimers and inhibit STAT mediated gene activation. Deletion of the first 50 amino acid residues containing the SAP domain allows the interaction of PIAS1 with STAT1 monomer
* Plant poly(ADP-ribose) polymerase (PARP). PARP is a nuclear protein that catalyzes the poly(ADP-ribosyl)ation of proteins. It is involved in responses to mild and severe oxidative stresses, by mediating DNA repair and programmed cell death processes, respectively
* Arabidopsis thaliana Arp, an apurinic endonuclease-redox protein.
* Yeast THO1 protein. It could be involved in the regulation of transcriptional elongation by RNA polymerase II
* Animal Ku70. Together with Ku86, it forms a DNA ends binding complex that is involved in repairing DNA double-strand breaks.
* Yeast RAD18, a protein involved in DNA repair.
* Neurospora crassa UVS-2, the homologue of RAD18.
References Imported from IPR036361
1.The involvement of poly(ADP-ribose) polymerase in the oxidative stress responses in plants. Amor Y, Babiychuk E, Inze D, Levine A. FEBS Lett. 440, 1-7, (1998). View articlePMID: 9862413
2.Distinct roles of the NH2- and COOH-terminal domains of the protein inhibitor of activated signal transducer and activator of transcription (STAT) 1 (PIAS1) in cytokine-induced PIAS1-Stat1 interaction. Liao J, Fu Y, Shuai K. Proc. Natl. Acad. Sci. U.S.A. 97, 5267-72, (2000). View articlePMID: 10805787
3.Acinus is a caspase-3-activated protein required for apoptotic chromatin condensation. Sahara S, Aoto M, Eguchi Y, Imamoto N, Yoneda Y, Tsujimoto Y. Nature 401, 168-73, (1999). View articlePMID: 10490026
4.Apoptotic cleavage of scaffold attachment factor A (SAF-A) by caspase-3 occurs at a noncanonical cleavage site. Kipp M, Schwab BL, Przybylski M, Nicotera P, Fackelmayer FO. J. Biol. Chem. 275, 5031-6, (2000). View articlePMID: 10671544
5.SAF-B protein couples transcription and pre-mRNA splicing to SAR/MAR elements. Nayler O, Stratling W, Bourquin JP, Stagljar I, Lindemann L, Jasper H, Hartmann AM, Fackelmayer FO, Ullrich A, Stamm S. Nucleic Acids Res. 26, 3542-9, (1998). View articlePMID: 9671816
6.A novel yeast gene, THO2, is involved in RNA pol II transcription and provides new evidence for transcriptional elongation-associated recombination. Piruat JI, Aguilera A. EMBO J. 17, 4859-72, (1998). View articlePMID: 9707445
7.A novel hnRNP protein (HAP/SAF-B) enters a subset of hnRNP complexes and relocates in nuclear granules in response to heat shock. Weighardt F, Cobianchi F, Cartegni L, Chiodi I, Villa A, Riva S, Biamonti G. J. Cell. Sci. 112 ( Pt 10), 1465-76, (1999). PMID: 10212141
8.SAP - a putative DNA-binding motif involved in chromosomal organization. Aravind L, Koonin EV. Trends Biochem. Sci. 25, 112-4, (2000). View articlePMID: 10694879