Member database | CATH-Gene3D |
CATH-Gene3D type | homologous superfamily |
Description Imported from IPR042241
This superfamily covers families of proteins all derived via gene-duplication events that act together in the gamma-tubulin complex. This complex is required for microtubule nucleation at the centrosome. The C-terminal domain is involved in the binding of gamma-tubulin, demonstrated by in vitro and deletion experiments with GCP4 (gamma-tubulin complex protein 4)
[1].
References Imported from IPR042241
1.Crystal structure of γ-tubulin complex protein GCP4 provides insight into microtubule nucleation. Guillet V, Knibiehler M, Gregory-Pauron L, Remy MH, Chemin C, Raynaud-Messina B, Bon C, Kollman JM, Agard DA, Merdes A, Mourey L. Nat. Struct. Mol. Biol. 18, 915-9, (2011). View articlePMID: 21725292