G3DSA:1.20.120.920

CRISPR-associated endonuclease Cas1, C-terminal domain

CATH-Gene3D entry
Member databaseCATH-Gene3D
CATH-Gene3D typehomologous superfamily

Description
Imported from IPR042206

The CRISPR-Cas system is a prokaryotic defense mechanism against foreign genetic elements. The key elements of this defense system are the Cas proteins and the CRISPR RNA.

This superfamily corresponds to the C-terminal domain found in Cas1, a CRISPR-associated protein. Cas1 is common to all CRISPR-containing prokaryotes and it may be involved in linking DNA segments to CRISPR.

References
Imported from IPR042206

1. CRISPR provides acquired resistance against viruses in prokaryotes. Barrangou R, Fremaux C, Deveau H, Richards M, Boyaval P, Moineau S, Romero DA, Horvath P. Science 315, 1709-12, (2007). View articlePMID: 17379808

2. Evolutionary conservation of sequence and secondary structures in CRISPR repeats. Kunin V, Sorek R, Hugenholtz P. Genome Biol. 8, R61, (2007). View articlePMID: 17442114

3. A complex of Cas proteins 5, 6, and 7 is required for the biogenesis and stability of clustered regularly interspaced short palindromic repeats (crispr)-derived rnas (crrnas) in Haloferax volcanii. Brendel J, Stoll B, Lange SJ, Sharma K, Lenz C, Stachler AE, Maier LK, Richter H, Nickel L, Schmitz RA, Randau L, Allers T, Urlaub H, Backofen R, Marchfelder A. J. Biol. Chem. 289, 7164-77, (2014). View articlePMID: 24459147

4. Helicase dissociation and annealing of RNA-DNA hybrids by Escherichia coli Cas3 protein. Howard JA, Delmas S, Ivancic-Bace I, Bolt EL. Biochem. J. 439, 85-95, (2011). View articlePMID: 21699496

5. A putative RNA-interference-based immune system in prokaryotes: computational analysis of the predicted enzymatic machinery, functional analogies with eukaryotic RNAi, and hypothetical mechanisms of action. Makarova KS, Grishin NV, Shabalina SA, Wolf YI, Koonin EV. Biol. Direct 1, 7, (2006). View articlePMID: 16545108

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