G3DSA:1.20.1230.10

Phospholipase C beta, distal C-terminal domain

CATH-Gene3D entry
Member databaseCATH-Gene3D
CATH-Gene3D typehomologous superfamily

Description
Imported from IPR042531

The distal α helical C-terminal domain (CTD) of phospholipase C beta (PLC-beta) has key roles in membrane targeting and in optimising the orientation of the catalytic core at the membrane for maximal rates of lipid hydrolysis. Structurally, it consists of a helical bundle with three antiparallel segments
[1]
.

References
Imported from IPR042531

1.Full-length Gα(q)-phospholipase C-β3 structure reveals interfaces of the C-terminal coiled-coil domain. Lyon AM, Dutta S, Boguth CA, Skiniotis G, Tesmer JJ. Nat. Struct. Mol. Biol. 20, 355-62, (2013). PMID: 23377541

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