G3DSA:1.20.91.10

G3DSA:1.20.91.10

CATH-Gene3D entry
Member databaseCATH-Gene3D
CATH-Gene3D typehomologous superfamily

Description
Imported from IPR015423

Matrix protein (M1) of Influenza virus is a bifunctional membrane/RNA-binding protein that mediates the encapsidation of RNA-nucleoprotein cores into the membrane envelope. It is therefore required that M1 binds both membrane and RNA simultaneously
[1]
. M1 is comprised of two domains connected by a linker sequence. The N-terminal domain has a multi-helical structure that can be divided into two subdomains: subdomain 1 forms an up-down helical bundle and subdomain 2 forms an orthogonal bundle
[2]
. The C-terminal domain also contains α-helical structure.

This entry represents the first subdomain of the N-terminal domain of M1.

References
Imported from IPR015423

1.Structure of a bifunctional membrane-RNA binding protein, influenza virus matrix protein M1. Sha B, Luo M. Nat. Struct. Biol. 4, 239-44, (1997). View articlePMID: 9164466

2.Combined results from solution studies on intact influenza virus M1 protein and from a new crystal form of its N-terminal domain show that M1 is an elongated monomer. Arzt S, Baudin F, Barge A, Timmins P, Burmeister WP, Ruigrok RW. Virology 279, 439-46, (2001). View articlePMID: 11162800

This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.