Member database | CATH-Gene3D |
CATH-Gene3D type | homologous superfamily |
Description Imported from IPR015423
Matrix protein (M1) of Influenza virus is a bifunctional membrane/RNA-binding protein that mediates the encapsidation of RNA-nucleoprotein cores into the membrane envelope. It is therefore required that M1 binds both membrane and RNA simultaneously
[1]. M1 is comprised of two domains connected by a linker sequence. The N-terminal domain has a multi-helical structure that can be divided into two subdomains: subdomain 1 forms an up-down helical bundle and subdomain 2 forms an orthogonal bundle
[2]. The C-terminal domain also contains α-helical structure.
This entry represents the first subdomain of the N-terminal domain of M1.
References Imported from IPR015423
1.Structure of a bifunctional membrane-RNA binding protein, influenza virus matrix protein M1. Sha B, Luo M. Nat. Struct. Biol. 4, 239-44, (1997). View articlePMID: 9164466
2.Combined results from solution studies on intact influenza virus M1 protein and from a new crystal form of its N-terminal domain show that M1 is an elongated monomer. Arzt S, Baudin F, Barge A, Timmins P, Burmeister WP, Ruigrok RW. Virology 279, 439-46, (2001). View articlePMID: 11162800