Member database | CATH-Gene3D |
CATH-Gene3D type | homologous superfamily |
Description Imported from IPR023375
Acetoacetate decarboxylase (ADC) is involved in solventogenesis in certain bacteria, which occurs at the end of the exponential growth phase when there is a metabolic switch from classical sugar fermentation with the production of acetate and butyrate to the re-internalisation and oxidation of these acids to acetate and butanol
[2]. In Clostridium, Spo0A controls the switch from acid to solvent production. A Spo0A-binding motif occurs in the gene encoding ADC
[1].
This superfamily represents the β-barrel structural domain found in acetoacetate decarboxylases.
References Imported from IPR023375
1.Spo0A directly controls the switch from acid to solvent production in solvent-forming clostridia. Ravagnani A, Jennert KC, Steiner E, Grunberg R, Jefferies JR, Wilkinson SR, Young DI, Tidswell EC, Brown DP, Youngman P, Morris JG, Young M. Mol. Microbiol. 37, 1172-85, (2000). View articlePMID: 10972834
2.Changes in protein synthesis and identification of proteins specifically induced during solventogenesis in Clostridium acetobutylicum. Schaffer S, Isci N, Zickner B, Durre P. Electrophoresis 23, 110-21, (2002). View articlePMID: 11824611