G3DSA:2.40.400.10

Acetoacetate decarboxylase-like

CATH-Gene3D entry
Member databaseCATH-Gene3D
CATH-Gene3D typehomologous superfamily

Description
Imported from IPR023375

Acetoacetate decarboxylase (ADC) is involved in solventogenesis in certain bacteria, which occurs at the end of the exponential growth phase when there is a metabolic switch from classical sugar fermentation with the production of acetate and butyrate to the re-internalisation and oxidation of these acids to acetate and butanol
[2]
. In Clostridium, Spo0A controls the switch from acid to solvent production. A Spo0A-binding motif occurs in the gene encoding ADC
[1]
.

This superfamily represents the β-barrel structural domain found in acetoacetate decarboxylases.

References
Imported from IPR023375

1.Spo0A directly controls the switch from acid to solvent production in solvent-forming clostridia. Ravagnani A, Jennert KC, Steiner E, Grunberg R, Jefferies JR, Wilkinson SR, Young DI, Tidswell EC, Brown DP, Youngman P, Morris JG, Young M. Mol. Microbiol. 37, 1172-85, (2000). View articlePMID: 10972834

2.Changes in protein synthesis and identification of proteins specifically induced during solventogenesis in Clostridium acetobutylicum. Schaffer S, Isci N, Zickner B, Durre P. Electrophoresis 23, 110-21, (2002). View articlePMID: 11824611

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