G3DSA:3.10.100.10

Mannose-Binding Protein A, subunit A

CATH-Gene3D entry
Member databaseCATH-Gene3D
CATH-Gene3D typehomologous superfamily

Description
Imported from IPR016186

Lectins occur in plants, animals, bacteria and viruses. Initially described for their carbohydrate-binding activity
[2]
, they are now recognised as a more diverse group of proteins, some of which are involved in protein-protein, protein-lipid or protein-nucleic acid interactions
[3]
. There are at least twelve structural families of lectins, of which C-type (Ca+-dependent) lectins is one. C-type lectins can be further divided into seven subgroups based on additional non-lectin domains and gene structure: (I) hyalectans, (II) asialoglycoprotein receptors, (III) collectins, (IV) selectins, (V) NK group transmembrane receptors, (VI) macrophage mannose receptors, and (VII) simple (single domain) lectins
[4]
.

The term 'C-type lectin domain' was introduced to distinguish a carbohydrate-recognition domain (CRD) which is present in all Ca2+-dependent lectins, but not in other types of animal lectins. However, there are proteins with modules similar in overall structure to CRDs that serve functions other than sugar binding. Therefore, a more general term C-type lectin-like domain was introduced to refer to such domains, although both terms are sometimes used interchangeably
[11]
.

This superfamily represents a structural domain found in C-type lectins, as well as in other proteins, including:


 * The C-terminal domain of invasin
[5]
and intimin
[9]
.
 * Link domain, which includes the Link module of tumor necrosis factor-inducible gene 6 protein (TSG-6)
[10]
(a hyaladherin with important roles in inflammation and ovulation) and the hyaluronan binding domain of CD44 (which contains extra N-terminal β-strand and C-terminal β-hairpin)
[6]
. The Link domain may have emerged as a result of a deletion of the long loop region from an ancestral canonical C-type lectin domain
[1]
.
 * Endostatin
[7]
and the endostatin domain of collagen alpha 1 (XV)
[8]
, these domains being decorated with many insertions in the common fold.

References
Imported from IPR016186

1.The protein fold of the hyaluronate-binding proteoglycan tandem repeat domain of link protein, aggrecan and CD44 is similar to that of the C-type lectin superfamily. Brissett NC, Perkins SJ. FEBS Lett. 388, 211-6, (1996). View articlePMID: 8690089

2.The structural basis for carbohydrate recognition by lectins. Sharon N, Lis H. Adv. Exp. Med. Biol. 491, 1-16, (2001). PMID: 14533786

3.Animal lectins: a historical introduction and overview. Kilpatrick DC. Biochim. Biophys. Acta 1572, 187-97, (2002). View articlePMID: 12223269

4.Divergent roles for C-type lectins expressed by cells of the innate immune system. McGreal EP, Martinez-Pomares L, Gordon S. Mol. Immunol. 41, 1109-21, (2004). View articlePMID: 15476922

5.Crystal structure of invasin: a bacterial integrin-binding protein. Hamburger ZA, Brown MS, Isberg RR, Bjorkman PJ. Science 286, 291-5, (1999). View articlePMID: 10514372

6.Structure of the regulatory hyaluronan binding domain in the inflammatory leukocyte homing receptor CD44. Teriete P, Banerji S, Noble M, Blundell CD, Wright AJ, Pickford AR, Lowe E, Mahoney DJ, Tammi MI, Kahmann JD, Campbell ID, Day AJ, Jackson DG. Mol. Cell 13, 483-96, (2004). View articlePMID: 14992719

7.Zinc-dependent dimers observed in crystals of human endostatin. Ding YH, Javaherian K, Lo KM, Chopra R, Boehm T, Lanciotti J, Harris BA, Li Y, Shapiro R, Hohenester E, Timpl R, Folkman J, Wiley DC. Proc. Natl. Acad. Sci. U.S.A. 95, 10443-8, (1998). View articlePMID: 9724722

8.Endostatins derived from collagens XV and XVIII differ in structural and binding properties, tissue distribution and anti-angiogenic activity. Sasaki T, Larsson H, Tisi D, Claesson-Welsh L, Hohenester E, Timpl R. J. Mol. Biol. 301, 1179-90, (2000). View articlePMID: 10966814

9.Crystal structure of enteropathogenic Escherichia coli intimin-receptor complex. Luo Y, Frey EA, Pfuetzner RA, Creagh AL, Knoechel DG, Haynes CA, Finlay BB, Strynadka NC. Nature 405, 1073-7, (2000). View articlePMID: 10890451

10.The link module from ovulation- and inflammation-associated protein TSG-6 changes conformation on hyaluronan binding. Blundell CD, Mahoney DJ, Almond A, DeAngelis PL, Kahmann JD, Teriete P, Pickford AR, Campbell ID, Day AJ. J. Biol. Chem. 278, 49261-70, (2003). View articlePMID: 12972412

11.The C-type lectin-like domain superfamily. Zelensky AN, Gready JE. FEBS J. 272, 6179-217, (2005). View articlePMID: 16336259

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