G3DSA:3.10.110.10

Ubiquitin Conjugating Enzyme

CATH-Gene3D entry
Member databaseCATH-Gene3D
CATH-Gene3D typehomologous superfamily

Description
Imported from IPR016135

This superfamily represents a structural domain with an α-β(4)-α(3) core fold. Domains of this structure are found in:


 * Ubiquitin conjugating enzyme E2, as well as related proteins such as ubiquitin carrier protein 4 and ubiquitin-protein ligase W
[1]
.
 * The UEV domain in tumour susceptibility gene 101
[2]
and vacuolar protein sorting-associated protein
[3]
.
 * RWD domain, found in RING finger and WD repeat-containing proteins, such as EIF-2 kinase 4 (GCN2-like protein)
[4]
.
 * UFC1-like domain found in Ufm1-conjugating enzyme 1
[5]
.

References
Imported from IPR016135

1.The NMR structure of the class I human ubiquitin-conjugating enzyme 2b. Miura T, Klaus W, Ross A, Guntert P, Senn H. J. Biomol. NMR 22, 89-92, (2002). View articlePMID: 11885984

2.Structure of human TSG101 UEV domain. Palencia A, Martinez JC, Mateo PL, Luque I, Camara-Artigas A. Acta Crystallogr. D Biol. Crystallogr. 62, 458-64, (2006). View articlePMID: 16552148

3.Structural insights into endosomal sorting complex required for transport (ESCRT-I) recognition of ubiquitinated proteins. Teo H, Veprintsev DB, Williams RL. J. Biol. Chem. 279, 28689-96, (2004). View articlePMID: 15044434

4.Solution structure of the RWD domain of the mouse GCN2 protein. Nameki N, Yoneyama M, Koshiba S, Tochio N, Inoue M, Seki E, Matsuda T, Tomo Y, Harada T, Saito K, Kobayashi N, Yabuki T, Aoki M, Nunokawa E, Matsuda N, Sakagami N, Terada T, Shirouzu M, Yoshida M, Hirota H, Osanai T, Tanaka A, Arakawa T, Carninci P, Kawai J, Hayashizaki Y, Kinoshita K, Guntert P, Kigawa T, Yokoyama S. Protein Sci. 13, 2089-100, (2004). View articlePMID: 15273307

5.Crystal structure of Ufc1, the Ufm1-conjugating enzyme. Mizushima T, Tatsumi K, Ozaki Y, Kawakami T, Suzuki A, Ogasahara K, Komatsu M, Kominami E, Tanaka K, Yamane T. Biochem. Biophys. Res. Commun. 362, 1079-84, (2007). View articlePMID: 17825256

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