G3DSA:3.10.50.40

G3DSA:3.10.50.40

CATH-Gene3D entry
Member databaseCATH-Gene3D
CATH-Gene3D typehomologous superfamily

Description
Imported from IPR046357

This superfamily represents the peptidyl-prolyl cis-trans isomerase domain found in a wide range of proteins, including trigger factor
[6, 2]
, FK506-binding proteins
[3, 8]
, proteins from the parvulin family such as Par10 from E.coli, Pin1 and Par14 from human or Pin from plants
[4]
, chaperone SurA
[5, 1]
and foldase protein PrsA
[7]
. This domain catalyses cis/trans isomerization of peptidyl-prolyl bonds, which is often rate-limiting for protein folding.

This domain consists of a flattened β-barrel of four/six-stranded, antiparallel sheets, surrounded by four/six α-helices.

References
Imported from IPR046357

1.Inter-domain dynamics in the chaperone SurA and multi-site binding to its outer membrane protein clients. Calabrese AN, Schiffrin B, Watson M, Karamanos TK, Walko M, Humes JR, Horne JE, White P, Wilson AJ, Kalli AC, Tuma R, Ashcroft AE, Brockwell DJ, Radford SE. Nat Commun 11, 2155, (2020). PMID: 32358557

2.The dynamic dimer structure of the chaperone Trigger Factor. Morgado L, Burmann BM, Sharpe T, Mazur A, Hiller S. Nat Commun 8, 1992, (2017). PMID: 29222465

3.NMR solution structure and dynamics of the peptidyl-prolyl cis-trans isomerase domain of the trigger factor from Mycoplasma genitalium compared to FK506-binding protein. Vogtherr M, Jacobs DM, Parac TN, Maurer M, Pahl A, Saxena K, Ruterjans H, Griesinger C, Fiebig KM. J. Mol. Biol. 318, 1097-115, (2002). View articlePMID: 12054805

4.Solution structure of Escherichia coli Par10: The prototypic member of the Parvulin family of peptidyl-prolyl cis/trans isomerases. Kuhlewein A, Voll G, Hernandez Alvarez B, Kessler H, Fischer G, Rahfeld JU, Gemmecker G. Protein Sci. 13, 2378-87, (2004). View articlePMID: 15322281

5.Crystallographic structure of SurA, a molecular chaperone that facilitates folding of outer membrane porins. Bitto E, McKay DB. Structure 10, 1489-98, (2002). View articlePMID: 12429090

6.Trigger factor in complex with the ribosome forms a molecular cradle for nascent proteins. Ferbitz L, Maier T, Patzelt H, Bukau B, Deuerling E, Ban N. Nature 431, 590-6, (2004). View articlePMID: 15334087

7.Structure-function analysis of PrsA reveals roles for the parvulin-like and flanking N- and C-terminal domains in protein folding and secretion in Bacillus subtilis. Vitikainen M, Lappalainen I, Seppala R, Antelmann H, Boer H, Taira S, Savilahti H, Hecker M, Vihinen M, Sarvas M, Kontinen VP. J. Biol. Chem. 279, 19302-14, (2004). View articlePMID: 14976191

8.Structural and functional studies of FkpA from Escherichia coli, a cis/trans peptidyl-prolyl isomerase with chaperone activity. Saul FA, Arie JP, Vulliez-le Normand B, Kahn R, Betton JM, Bentley GA. J. Mol. Biol. 335, 595-608, (2004). View articlePMID: 14672666

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