G3DSA:3.30.1310.10

Nucleoid-associated protein YbaB-like domain

CATH-Gene3D entry
Member databaseCATH-Gene3D
CATH-Gene3D typehomologous superfamily

Description
Imported from IPR036894

This entry represents a domain superfamily of DNA-binding proteins. It is restricted to bacteria and plants. Members of this family form homodimers which bind DNA via a tweezer-like structure
[1, 3, 2]
. The conformation of the DNA is changed when bound to these proteins
[2]
. In bacteria, these proteins may play a role in DNA replication-recovery following DNA damage
[1]
. The plant form contains an additional N-terminal region that may serve as a transit peptide and shows a close relationship to the cyanobacterial member, suggesting that it is a chloroplast protein.

The crystal structure YbaB from Haemophilus influenzae revealed a tight dimer with a three-layer structure (β/α/β)
[1]
.

References
Imported from IPR036894

1.Crystal structure of YbaB from Haemophilus influenzae (HI0442), a protein of unknown function coexpressed with the recombinational DNA repair protein RecR. Lim K, Tempczyk A, Parsons JF, Bonander N, Toedt J, Kelman Z, Howard A, Eisenstein E, Herzberg O. Proteins 50, 375-9, (2003). View articlePMID: 12486730

2.Borrelia burgdorferi EbfC defines a newly-identified, widespread family of bacterial DNA-binding proteins. Riley SP, Bykowski T, Cooley AE, Burns LH, Babb K, Brissette CA, Bowman A, Rotondi M, Miller MC, DeMoll E, Lim K, Fried MG, Stevenson B. Nucleic Acids Res. 37, 1973-83, (2009). View articlePMID: 19208644

3.DNA-binding by Haemophilus influenzae and Escherichia coli YbaB, members of a widely-distributed bacterial protein family. Cooley AE, Riley SP, Kral K, Miller MC, DeMoll E, Fried MG, Stevenson B. BMC Microbiol. 9, 137, (2009). View articlePMID: 19594923

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