G3DSA:3.30.1360.120

Probable tRNA modification gtpase trme; domain 1

CATH-Gene3D entry
Member databaseCATH-Gene3D
CATH-Gene3D typehomologous superfamily

Description
Imported from IPR027266

This entry represents an α/β domain found in GTP-binding protein TrmE (N-terminal domain)
[1]
and domain 1 of glycine cleavage T-protein (also known as aminomethyltransferase)
[2]
.

TrmE is a guanine nucleotide-binding protein conserved between bacteria and eukaryotes. It is involved in the modification of uridine bases at the first anticodon (wobble) position of tRNAs. The N-terminal portion of the protein is necessary for mediating dimer formation within the protein
[1]
.

References
Imported from IPR027266

1.The structure of the TrmE GTP-binding protein and its implications for tRNA modification. Scrima A, Vetter IR, Armengod ME, Wittinghofer A. EMBO J. 24, 23-33, (2005). View articlePMID: 15616586

2.Crystal structure of T-protein of the glycine cleavage system. Cofactor binding, insights into H-protein recognition, and molecular basis for understanding nonketotic hyperglycinemia. Lee HH, Kim DJ, Ahn HJ, Ha JY, Suh SW. J. Biol. Chem. 279, 50514-23, (2004). View articlePMID: 15355973

Further reading

3. The glycine decarboxylase system: a fascinating complex. Douce R, Bourguignon J, Neuburger M, Rebeille F. Trends Plant Sci. 6, 167-76, (2001). View articlePMID: 11286922

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