G3DSA:3.30.1600.10

SIR2/SIRT2 'Small Domain'

CATH-Gene3D entry
Member databaseCATH-Gene3D
CATH-Gene3D typehomologous superfamily

Description
Imported from IPR026591

The catalytic core of sirtuin proteins consists of a large and a small domains. The large domain has a Rossmann fold and binds NAD+. The small domain is composed of residues from two insertions in the Rossmann fold that form a helical and a zinc binding modules
[1, 2]
. This superfamily represents the catalytic core small domain.

References
Imported from IPR026591

1.Crystal structure of a SIR2 homolog-NAD complex. Min J, Landry J, Sternglanz R, Xu RM. Cell 105, 269-79, (2001). View articlePMID: 11336676

2.Structure of a Sir2 enzyme bound to an acetylated p53 peptide. Avalos JL, Celic I, Muhammad S, Cosgrove MS, Boeke JD, Wolberger C. Mol. Cell 10, 523-35, (2002). View articlePMID: 12408821

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