G3DSA:3.30.230.70

GHMP Kinase, N-terminal domain

CATH-Gene3D entry
Member databaseCATH-Gene3D
CATH-Gene3D typehomologous superfamily

Description
Imported from IPR027408

Polynucleotide phosphorylase (PNPase) is a polyribonucleotide nucleotidyl transferase
2.7.7.8
that degrades mRNA in prokaryotes. Polynucleotide phosphorylase and the Ribonuclease PH (RNase PH) family possess a common domain represented by this entry. This suggests similar structures and mechanisms of action for these 3'-->5' phosphorolytic enzymes
[1]
. In the case of PNPase, the core domain is found duplicated
[2]
.

References
Imported from IPR027408

1.Comparative sequence analysis of ribonucleases HII, III, II PH and D. Mian IS. Nucleic Acids Res. 25, 3187-95, (1997). View articlePMID: 9241229

2.A duplicated fold is the structural basis for polynucleotide phosphorylase catalytic activity, processivity, and regulation. Symmons MF, Jones GH, Luisi BF. Structure 8, 1215-26, (2000). View articlePMID: 11080643

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