Member database | CATH-Gene3D |
CATH-Gene3D type | homologous superfamily |
Description Imported from IPR027408
Polynucleotide phosphorylase (PNPase) is a polyribonucleotide nucleotidyl transferase
2.7.7.8 that degrades mRNA in prokaryotes. Polynucleotide phosphorylase and the Ribonuclease PH (RNase PH) family possess a common domain represented by this entry. This suggests similar structures and mechanisms of action for these 3'-->5' phosphorolytic enzymes
[1]. In the case of PNPase, the core domain is found duplicated
[2].
References Imported from IPR027408
1.Comparative sequence analysis of ribonucleases HII, III, II PH and D. Mian IS. Nucleic Acids Res. 25, 3187-95, (1997). View articlePMID: 9241229
2.A duplicated fold is the structural basis for polynucleotide phosphorylase catalytic activity, processivity, and regulation. Symmons MF, Jones GH, Luisi BF. Structure 8, 1215-26, (2000). View articlePMID: 11080643
Integrated to
External Links
Representative structure
3hkm: Crystal Structure of rice(Oryza sativa) Rrp46