Member database | CATH-Gene3D |
CATH-Gene3D type | homologous superfamily |
Description Imported from IPR027481
Human immunodeficiency virus 1 (HIV-1) negative factor (Nef protein) accelerates virulent progression of acquired immunodeficiency syndrome (AIDS) by its interaction with specific cellular proteins involved in signal transduction and host cell activation. Nef has been shown to bind specifically to a subset of the Src family of kinases
[3].
References Imported from IPR027481
1.Stability and proteolytic domains of Nef protein from human immunodeficiency virus (HIV) type 1. Freund J, Kellner R, Houthaeve T, Kalbitzer HR. Eur. J. Biochem. 221, 811-9, (1994). View articlePMID: 8174561
2.Structure of the anchor-domain of myristoylated and non-myristoylated HIV-1 Nef protein. Geyer M, Munte CE, Schorr J, Kellner R, Kalbitzer HR. J. Mol. Biol. 289, 123-38, (1999). View articlePMID: 10339411
3.The crystal structure of HIV-1 Nef protein bound to the Fyn kinase SH3 domain suggests a role for this complex in altered T cell receptor signaling. Arold S, Franken P, Strub MP, Hoh F, Benichou S, Benarous R, Dumas C. Structure 5, 1361-72, (1997). View articlePMID: 9351809