G3DSA:3.30.62.10

Nef Regulatory Factor

CATH-Gene3D entry
Member databaseCATH-Gene3D
CATH-Gene3D typehomologous superfamily

Description
Imported from IPR027481

Human immunodeficiency virus 1 (HIV-1) negative factor (Nef protein) accelerates virulent progression of acquired immunodeficiency syndrome (AIDS) by its interaction with specific cellular proteins involved in signal transduction and host cell activation. Nef has been shown to bind specifically to a subset of the Src family of kinases
[3]
.

Negative factor (Nef) has a two-domain structure consisting of an N-terminal anchor domain and a core domain separated by a specific cleavage site of the HIV proteases. The N-terminal domain is not compactly folded and constitutes a mobile membrane anchor and a linker to the core domain
[1, 2]
.

References
Imported from IPR027481

1.Stability and proteolytic domains of Nef protein from human immunodeficiency virus (HIV) type 1. Freund J, Kellner R, Houthaeve T, Kalbitzer HR. Eur. J. Biochem. 221, 811-9, (1994). View articlePMID: 8174561

2.Structure of the anchor-domain of myristoylated and non-myristoylated HIV-1 Nef protein. Geyer M, Munte CE, Schorr J, Kellner R, Kalbitzer HR. J. Mol. Biol. 289, 123-38, (1999). View articlePMID: 10339411

3.The crystal structure of HIV-1 Nef protein bound to the Fyn kinase SH3 domain suggests a role for this complex in altered T cell receptor signaling. Arold S, Franken P, Strub MP, Hoh F, Benichou S, Benarous R, Dumas C. Structure 5, 1361-72, (1997). View articlePMID: 9351809

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