Member database | CATH-Gene3D |
CATH-Gene3D type | homologous superfamily |
Description Imported from IPR023091
This superfamily represents a domain found in a number of predicted metalloproteases. The crystal structure of the protein from the hyperthermophilic bacteria Aquifex aeolicus has been determined. The overall fold consists of one central α-helix surrounded by a four-stranded β-sheet and four other α-helices. Structure-based homology analysis reveals a good resemblance to metalloproteases such as collagenases and gelatinases. However, experimental tests for collagenase and gelatinase-type function show no detectable activity under standard assay conditions
[1].
References Imported from IPR023091
1.Structure of the hypothetical protein AQ_1354 from Aquifex aeolicus. Oganesyan V, Busso D, Brandsen J, Chen S, Jancarik J, Kim R, Kim SH. Acta Crystallogr. D Biol. Crystallogr. 59, 1219-23, (2003). View articlePMID: 12832766
Integrated to
External Links
Representative structure
1oz9: Crystal structure of AQ_1354, a hypothetical protein from Aquifex aeolicus