G3DSA:3.40.390.30

Metalloproteases ("zincins"), catalytic domain

CATH-Gene3D entry
Member databaseCATH-Gene3D
CATH-Gene3D typehomologous superfamily

Description
Imported from IPR023091

This superfamily represents a domain found in a number of predicted metalloproteases. The crystal structure of the protein from the hyperthermophilic bacteria Aquifex aeolicus has been determined. The overall fold consists of one central α-helix surrounded by a four-stranded β-sheet and four other α-helices. Structure-based homology analysis reveals a good resemblance to metalloproteases such as collagenases and gelatinases. However, experimental tests for collagenase and gelatinase-type function show no detectable activity under standard assay conditions
[1]
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References
Imported from IPR023091

1.Structure of the hypothetical protein AQ_1354 from Aquifex aeolicus. Oganesyan V, Busso D, Brandsen J, Chen S, Jancarik J, Kim R, Kim SH. Acta Crystallogr. D Biol. Crystallogr. 59, 1219-23, (2003). View articlePMID: 12832766

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