G3DSA:3.40.47.10

G3DSA:3.40.47.10

CATH-Gene3D entry
Member databaseCATH-Gene3D
CATH-Gene3D typehomologous superfamily

Description
Imported from IPR016039

This superfamily represents a structural domain with a thiolase-like 3-layer α/β/α topology. This domain usually occurs in two similar copies that are related by a pseudo-dyad, and which arose through duplication. The proteins in this entry can be split into two groups: those related to thiolase, and those related to chalcone synthase. The thiolase-like enzymes include:


 * Thiolase, where the topology of each domain is similar to the first domain of phosphoglucomutase
[2]

 * Beta-ketoacyl-ACP synthases types I (
2.3.1.41
), II (
2.3.1.179
)
[3, 4]
and III (
2.3.1.180
)
 * Actinorhodin polyketide beta-ketoacyl synthases 1 and 2
[5]

 * Fatty oxidation complex beta subunit (3-ketoacyl-CoA thiolase;
2.3.1.16
)
[1]



The chalcone synthase-like enzymes include:


 * Chalcone synthase (
2.3.1.74
)
[6]

 * Ketoacyl-ACP synthase III (FabH;
2.3.1.180
)
[7]

 * Polyketide synthases
[8]

 * 3-hydroxy-3-methylglutaryl CoA synthase (
2.3.3.10
)
[9]

 * Dihydropinosylvin synthase
[10]


References
Imported from IPR016039

1.Structural basis for channelling mechanism of a fatty acid beta-oxidation multienzyme complex. Ishikawa M, Tsuchiya D, Oyama T, Tsunaka Y, Morikawa K. EMBO J. 23, 2745-54, (2004). View articlePMID: 15229654

2.The 1.8 A crystal structure of the dimeric peroxisomal 3-ketoacyl-CoA thiolase of Saccharomyces cerevisiae: implications for substrate binding and reaction mechanism. Mathieu M, Modis Y, Zeelen JP, Engel CK, Abagyan RA, Ahlberg A, Rasmussen B, Lamzin VS, Kunau WH, Wierenga RK. J. Mol. Biol. 273, 714-28, (1997). View articlePMID: 9402066

3.Fatty acid synthesis. Role of active site histidines and lysine in Cys-His-His-type beta-ketoacyl-acyl carrier protein synthases. von Wettstein-Knowles P, Olsen JG, McGuire KA, Henriksen A. FEBS J. 273, 695-710, (2006). View articlePMID: 16441657

4.Crystal structure of beta-ketoacyl-acyl carrier protein synthase II from E.coli reveals the molecular architecture of condensing enzymes. Huang W, Jia J, Edwards P, Dehesh K, Schneider G, Lindqvist Y. EMBO J. 17, 1183-91, (1998). View articlePMID: 9482715

5.An antibiotic factory caught in action. Keatinge-Clay AT, Maltby DA, Medzihradszky KF, Khosla C, Stroud RM. Nat. Struct. Mol. Biol. 11, 888-93, (2004). View articlePMID: 15286722

6.Structure-guided programming of polyketide chain-length determination in chalcone synthase. Jez JM, Bowman ME, Noel JP. Biochemistry 40, 14829-38, (2001). View articlePMID: 11732902

7.Refined structures of beta-ketoacyl-acyl carrier protein synthase III. Qiu X, Janson CA, Smith WW, Head M, Lonsdale J, Konstantinidis AK. J. Mol. Biol. 307, 341-56, (2001). View articlePMID: 11243824

8.A novel tunnel in mycobacterial type III polyketide synthase reveals the structural basis for generating diverse metabolites. Sankaranarayanan R, Saxena P, Marathe UB, Gokhale RS, Shanmugam VM, Rukmini R. Nat. Struct. Mol. Biol. 11, 894-900, (2004). View articlePMID: 15286723

9.Staphylococcus aureus 3-hydroxy-3-methylglutaryl-CoA synthase: crystal structure and mechanism. Campobasso N, Patel M, Wilding IE, Kallender H, Rosenberg M, Gwynn MN. J. Biol. Chem. 279, 44883-8, (2004). View articlePMID: 15292254

10.An aldol switch discovered in stilbene synthases mediates cyclization specificity of type III polyketide synthases. Austin MB, Bowman ME, Ferrer JL, Schroder J, Noel JP. Chem. Biol. 11, 1179-94, (2004). View articlePMID: 15380179

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