Member database | CATH-Gene3D |
CATH-Gene3D type | homologous superfamily |
Description Imported from IPR016162
This superfamily represents a structural domain found at the N-terminal of aldehyde dehydrogenases
[1]. These proteins contain two similar domains, each with a 3-layer α/β/α structure, which probably arose from a duplication; this entry covers the N-terminal a/b/a domain. These enzymes binds NAD differently from other NAD(P)-dependent oxidoreductases.
References Imported from IPR016162
1.Coenzyme isomerization is integral to catalysis in aldehyde dehydrogenase. Perez-Miller SJ, Hurley TD. Biochemistry 42, 7100-9, (2003). View articlePMID: 12795606
Further reading
2. Inducible (class 3) aldehyde dehydrogenase from rat hepatocellular carcinoma and 2,3,7,8-tetrachlorodibenzo-p-dioxin-treated liver: distant relationship to the class 1 and 2 enzymes from mammalian liver cytosol/mitochondria. Hempel J, Harper K, Lindahl R. Biochemistry 28, 1160-7, (1989). View articlePMID: 2713359
Integrated to
External Links
Representative structure
3v4c: Crystal structure of a semialdehyde dehydrogenase from Sinorhizobium meliloti 1021