G3DSA:3.40.605.10

Aldehyde Dehydrogenase; Chain A, domain 1

CATH-Gene3D entry
Member databaseCATH-Gene3D
CATH-Gene3D typehomologous superfamily

Description
Imported from IPR016162

This superfamily represents a structural domain found at the N-terminal of aldehyde dehydrogenases
[1]
. These proteins contain two similar domains, each with a 3-layer α/β/α structure, which probably arose from a duplication; this entry covers the N-terminal a/b/a domain. These enzymes binds NAD differently from other NAD(P)-dependent oxidoreductases.

References
Imported from IPR016162

1.Coenzyme isomerization is integral to catalysis in aldehyde dehydrogenase. Perez-Miller SJ, Hurley TD. Biochemistry 42, 7100-9, (2003). View articlePMID: 12795606

Further reading

2. Inducible (class 3) aldehyde dehydrogenase from rat hepatocellular carcinoma and 2,3,7,8-tetrachlorodibenzo-p-dioxin-treated liver: distant relationship to the class 1 and 2 enzymes from mammalian liver cytosol/mitochondria. Hempel J, Harper K, Lindahl R. Biochemistry 28, 1160-7, (1989). View articlePMID: 2713359

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