Member database | CATH-Gene3D |
CATH-Gene3D type | homologous superfamily |
Description Imported from IPR036961
* Drosophila melanogaster claret segregational protein (ncd). Ncd is required for normal chromosomal segregation in meiosis, in females, and in early mitotic divisions of the embryo. The ncd motor activity is directed toward the microtubule's minus end.
* Homo sapiens CENP-E
* H. sapiens mitotic kinesin-like protein-1 (MKLP-1), a motor protein whose activity is directed toward the microtubule's plus end.
* Saccharomyces cerevisiae KAR3 protein, which is essential for nuclear fusion during mating. KAR3 may mediate microtubule sliding during nuclear fusion and possibly mitosis.
* S. cerevisiae CIN8 and KIP1 proteins which are required for the assembly of the mitotic spindle. Both proteins seem to interact with spindle microtubules to produce an outwardly directed force acting upon the poles.
* Emericella nidulans (Aspergillus nidulans) bimC, which plays an important role in nuclear division.
* A. nidulans klpA.
* Caenorhabditis elegans unc-104, which may be required for the transport of substances needed for neuronal cell differentiation.
* C. elegans osm-3.
* Xenopus laevis Eg5, which may be involved in mitosis.
* Arabidopsis thaliana KatA, KatB and katC.
* Chlamydomonas reinhardtii FLA10/KHP1 and KLP1. Both proteins seem to play a role in the rotation or twisting of the microtubules of the flagella.
* C. elegans hypothetical protein T09A5.2.
References Imported from IPR036961
1.A kinesin medley: biochemical and functional heterogeneity. Brady ST. Trends Cell Biol. 5, 159-64, (1995). View articlePMID: 14732151
2.Crystal structure of the motor domain of the human kinetochore protein CENP-E. Garcia-Saez I, Yen T, Wade RH, Kozielski F. J. Mol. Biol. 340, 1107-16, (2004). View articlePMID: 15236970
3.The emerging kinesin family of microtubule motor proteins. Endow SA. Trends Biochem. Sci. 16, 221-5, (1991). View articlePMID: 1832505
4.A novel kinesin 13 protein regulating rice seed length. Kitagawa K, Kurinami S, Oki K, Abe Y, Ando T, Kono I, Yano M, Kitano H, Iwasaki Y. Plant Cell Physiol. 51, 1315-29, (2010). View articlePMID: 20587735
6.Motor proteins of cytoplasmic microtubules. Vallee RB, Shpetner HS. Annu. Rev. Biochem. 59, 909-32, (1990). View articlePMID: 2142876
7.Crystal structure of the kinesin motor domain reveals a structural similarity to myosin. Kull FJ, Sablin EP, Lau R, Fletterick RJ, Vale RD. Nature 380, 550-5, (1996). View articlePMID: 8606779