G3DSA:3.40.91.90

Influenza RNA-dependent RNA polymerase subunit PA, endonuclease domain

CATH-Gene3D entry
Member databaseCATH-Gene3D
CATH-Gene3D typehomologous superfamily

Description
Imported from IPR038372

The influenza virus contains a segmented RNA genome with eight negative-sense segments encoding 11 proteins. The influenza virus polymerase is a heterotrimeric complex comprised by the protein subunits: PA, PB1, and PB2. It plays central roles in the viral life cycle and is directly responsible for RNA synthesis for both viral replication and transcription
[3]
.

The PA subunit can be cleaved into two independent domains: a smaller N-terminal domain with cap-dependent endonuclease activity and a larger C-terminal domain that mediates the interaction with PB1. Structural domains comprising this superfamily share the structure of the N-terminal endonuclease domain of PA
[3, 1, 2]
.

References
Imported from IPR038372

1.Structural Analysis of Specific Metal Chelating Inhibitor Binding to the Endonuclease Domain of Influenza pH1N1 (2009) Polymerase. Kowalinski E, Zubieta C, Wolkerstorfer A, Szolar OH, Ruigrok RW, Cusack S. PLoS Pathog. 8, e1002831, (2012). View articlePMID: 22876177

2.Identification and characterization of influenza variants resistant to a viral endonuclease inhibitor. Song MS, Kumar G, Shadrick WR, Zhou W, Jeevan T, Li Z, Slavish PJ, Fabrizio TP, Yoon SW, Webb TR, Webby RJ, White SW. Proc Natl Acad Sci U S A 113, 3669-74, (2016). PMID: 26976575

3.Nucleoside monophosphate complex structures of the endonuclease domain from the influenza virus polymerase PA subunit reveal the substrate binding site inside the catalytic center. Zhao C, Lou Z, Guo Y, Ma M, Chen Y, Liang S, Zhang L, Chen S, Li X, Liu Y, Bartlam M, Rao Z. J. Virol. 83, 9024-30, (2009). View articlePMID: 19587036

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