G3DSA:3.90.260.10

Transglutaminase-like

CATH-Gene3D entry
Member databaseCATH-Gene3D
CATH-Gene3D typehomologous superfamily

Description
Imported from IPR036985

This domain superfamily is found in many proteins known to have transglutaminase activity, i.e. which cross-link proteins through an acyl-transfer reaction between the gamma-carboxamide group of peptide-bound glutamine and the ε-amino group of peptide-bound lysine, resulting in a ε-(gamma-glutamyl)lysine isopeptide bond. Tranglutaminases have been found in a diverse range of species, from bacteria through to mammals. The enzymes require calcium binding and their activity leads to post-translational modification of proteins through acyl-transfer reactions, involving peptidyl glutamine residues as acyl donors and a variety of primary amines as acyl acceptors, with the generation of proteinase resistant isopeptide bonds
[1]
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References
Imported from IPR036985

1.Transglutaminases: nature's biological glues. Griffin M, Casadio R, Bergamini CM. Biochem. J. 368, 377-96, (2002). View articlePMID: 12366374

Further reading

2. Molecular analysis of Methanobacterium phage psiM2. Pfister P, Wasserfallen A, Stettler R, Leisinger T. Mol. Microbiol. 30, 233-44, (1998). View articlePMID: 9791169

3. Three-dimensional structure of a transglutaminase: human blood coagulation factor XIII. Yee VC, Pedersen LC, Le Trong I, Bishop PD, Stenkamp RE, Teller DC. Proc. Natl. Acad. Sci. U.S.A. 91, 7296-300, (1994). View articlePMID: 7913750

4. A superfamily of archaeal, bacterial, and eukaryotic proteins homologous to animal transglutaminases. Makarova KS, Aravind L, Koonin EV. Protein Sci. 8, 1714-9, (1999). View articlePMID: 10452618

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