G3DSA:4.10.1240.10

GPCR, family 2, extracellular hormone receptor domain

CATH-Gene3D entry
Member databaseCATH-Gene3D
CATH-Gene3D typehomologous superfamily

Description
Imported from IPR036445

This domain superfamily is found in the extracellular part of some of the secretin-like (family 2) GPCRs including the corticotropin releasing factor receptor 1; calcitonin receptor; diuretic hormone receptor; glucagon-like peptide 1 receptor; and parathyroid hormone peptide receptor. The N-terminal extracellular domain is the major ligand recognition domain
[1]
. This domain structure has a disulfide-rich all-β fold and contains a β sandwich of 5 strands.

References
Imported from IPR036445

1.NMR structure and peptide hormone binding site of the first extracellular domain of a type B1 G protein-coupled receptor. Grace CR, Perrin MH, DiGruccio MR, Miller CL, Rivier JE, Vale WW, Riek R. Proc. Natl. Acad. Sci. U.S.A. 101, 12836-41, (2004). View articlePMID: 15326300

This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.