Member database | CATH-Gene3D |
CATH-Gene3D type | homologous superfamily |
Description Imported from IPR044893
RNA polymerases catalyse the DNA-dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial and chloroplast polymerases). This clamp domain is a mobile domain involved in positioning the DNA, maintenance of the transcription bubble and positioning of the nascent RNA strand
[1, 2, 3].
References Imported from IPR044893
1.Structural modules of the large subunits of RNA polymerase. Introducing archaebacterial and chloroplast split sites in the beta and beta' subunits of Escherichia coli RNA polymerase. Severinov K, Mustaev A, Kukarin A, Muzzin O, Bass I, Darst SA, Goldfarb A. J. Biol. Chem. 271, 27969-74, (1996). View articlePMID: 8910400
2.Structural basis of transcription: RNA polymerase II at 2.8 angstrom resolution. Cramer P, Bushnell DA, Kornberg RD. Science 292, 1863-76, (2001). View articlePMID: 11313498
3.RNA polymerase I structure and transcription regulation. Engel C, Sainsbury S, Cheung AC, Kostrewa D, Cramer P. Nature 502, 650-5, (2013). View articlePMID: 24153182