cd00019

AP2Ec

CDD entry
Member databaseCDD
CDD typedomain
Short nameAP2Ec
SetAP2Ec

Description

AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of D-arabino-6-hexulose 3-phosphate to D-fructose 6-phosphate, via cleaving the phosphoesterbond with the sugar.
[1]

References

1.Abasic site recognition by two apurinic/apyrimidinic endonuclease families in DNA base excision repair: the 3' ends justify the means. Mol CD, Hosfield DJ, Tainer JA. Mutat Res 460, 211-29, (2000). PMID: 10946230

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