cd00055

EGF_Lam

CDD entry
Member databaseCDD
CDD typedomain
Short nameEGF_Lam
SetEGF_CA

Description

Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in tandem arrays; the domain contains 4 disulfide bonds (loops a-d) the first three resemble epidermal growth factor (EGF); the number of copies of this domain in the different forms of laminins is highly variable ranging from 3 up to 22 copies
[1, 2]

References

1.Form and function: the laminin family of heterotrimers. Colognato H, Yurchenco PD. Dev. Dyn. 218, 213-34, (2000). View articlePMID: 10842354

2.Crystal structure of three consecutive laminin-type epidermal growth factor-like (LE) modules of laminin gamma1 chain harboring the nidogen binding site. Stetefeld J, Mayer U, Timpl R, Huber R. J. Mol. Biol. 257, 644-57, (1996). View articlePMID: 8648630

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