cd00062

FN2

CDD entry
Member databaseCDD
CDD typedomain
Short nameFN2
SetFN2

Description

Fibronectin Type II domain: FN2 is one of three types of internal repeats which combine to form larger domains within fibronectin. Fibronectin, a plasma protein that binds cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin, usually exists as a dimer in plasma and as an insoluble multimer in extracellular matrices. Dimers of nearly identical subunits are linked by a disulfide bond close to their C-terminus. Fibronectin is composed of 3 types of modules, FN1,FN2 and FN3. The collagen binding domain contains four FN1 and two FN2 repeats.
[7, 6, 3, 4, 1, 8, 2, 9, 5]

References

1.Evidence for the involvement of type II domains in collagen binding by 72 kDa type IV procollagenase. Banyai L, Patthy L. FEBS Lett. 282, 23-5, (1991). View articlePMID: 1851108

2.Mapping the collagen-binding site of human fibronectin by expression in Escherichia coli. Owens RJ, Baralle FE. EMBO J. 5, 2825-30, (1986). PMID: 3024962

3.Collagen-binding recombinant fibronectin fragments containing type II domains. Skorstengaard K, Holtet TL, Etzerodt M, Thogersen HC. FEBS Lett. 343, 47-50, (1994). View articlePMID: 8163015

4.Refined solution structure and ligand-binding properties of PDC-109 domain b. A collagen-binding type II domain. Constantine KL, Madrid M, Banyai L, Trexler M, Patthy L, Llinas M. J. Mol. Biol. 223, 281-98, (1992). View articlePMID: 1731074

5.Location of a collagen-binding domain in fibronectin. Balian G, Click EM, Bornstein P. J. Biol. Chem. 255, 3234-6, (1980). PMID: 6444947

6.Fibronectin structure and assembly. Potts JR, Campbell ID. Curr. Opin. Cell Biol. 6, 648-55, (1994). View articlePMID: 7833045

7.Solution structure of the glycosylated second type 2 module of fibronectin. Sticht H, Pickford AR, Potts JR, Campbell ID. J. Mol. Biol. 276, 177-87, (1998). View articlePMID: 9514732

8.The collagen-binding site of type-II units of bovine seminal fluid protein PDC-109 and fibronectin. Banyai L, Trexler M, Koncz S, Gyenes M, Sipos G, Patthy L. Eur. J. Biochem. 193, 801-6, (1990). View articlePMID: 2249694

9.Partial primary structure of bovine plasma fibronectin: three types of internal homology. Petersen TE, Thogersen HC, Skorstengaard K, Vibe-Pedersen K, Sahl P, Sottrup-Jensen L, Magnusson S. Proc. Natl. Acad. Sci. U.S.A. 80, 137-41, (1983). View articlePMID: 6218503

This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.