cd00083

basic Helix Loop Helix (bHLH) domain superfamily

CDD entry
Member databaseCDD
CDD typedomain
Short namebHLH_SF
SetbHLH_SF

Description

bHLH proteins are transcriptional regulators that are found in organisms from yeast to humans. Members of the bHLH superfamily have two highly conserved and functionally distinct regions. The basic part is at the amino end of the bHLH that may bind DNA to a consensus hexanucleotide sequence known as the E box (CANNTG). Different families of bHLH proteins recognize different E-box consensus sequences. At the carboxyl-terminal end of the region is the HLH region that interacts with other proteins to form homo- and heterodimers. bHLH proteins function as a diverse set of regulatory factors because they recognize different DNA sequences and dimerize with different proteins. The bHLH proteins can be divided to cell-type specific and widely expressed proteins. The cell-type specific members of bHLH superfamily are involved in cell-fate determination and act in neurogenesis, cardiogenesis, myogenesis, and hematopoiesis.
[3, 4, 5, 2, 6, 8, 7, 1]

References

1.The role of an E-box element: multiple frunctions and interacting partners. Seitz SB, Voytsekh O, Mohan KM, Mittag M. Plant Signal Behav 5, 1077-80, (2010). PMID: 20818183

2.A natural classification of the basic helix-loop-helix class of transcription factors. Atchley WR, Fitch WM. Proc Natl Acad Sci U S A 94, 5172-6, (1997). PMID: 9144210

3.Basic helix-loop-helix transcription factor gene family phylogenetics and nomenclature. Skinner MK, Rawls A, Wilson-Rawls J, Roalson EH. Differentiation 80, 1-8, (2010). PMID: 20219281

4.Phylogenetic and expression analysis of the basic helix-loop-helix transcription factor gene family: genomic approach to cellular differentiation. Stevens JD, Roalson EH, Skinner MK. Differentiation 76, 1006-22, (2008). PMID: 18557763

5.An overview of the basic helix-loop-helix proteins. Jones S. Genome Biol 5, 226, (2004). PMID: 15186484

6.Origin and diversification of the basic helix-loop-helix gene family in metazoans: insights from comparative genomics. Simionato E, Ledent V, Richards G, Thomas-Chollier M, Kerner P, Coornaert D, Degnan BM, Vervoort M. BMC Evol Biol 7, 33, (2007). PMID: 17335570

7.Analysis of sequence signature defining functional specificity and structural stability in helix-loop-helix proteins. Chavali GB, Vijayalakshmi C, Salunke DM. Proteins 42, 471-80, (2001). PMID: 11170202

8.Phylogenetic analysis of the human basic helix-loop-helix proteins. Ledent V, Paquet O, Vervoort M. Genome Biol 3, RESEARCH0030, (2002). PMID: 12093377

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