cd00148

PROF

CDD entry
Member databaseCDD
CDD typedomain
Short namePROF
SetPROF

Description

Profilin binds actin monomers, membrane polyphosphoinositides such as PI(4,5)P2, and poly-L-proline. Profilin can inhibit actin polymerization into F-actin by binding to monomeric actin (G-actin) and terminal F-actin subunits, but - as a regulator of the cytoskeleton - it may also promote actin polymerization. It plays a role in the assembly of branched actin filament networks, by activating WASP via binding to WASP's proline rich domain. Profilin may link the cytoskeleton with major signalling pathways by interacting with components of the phosphatidylinositol cycle and Ras pathway.
[1, 3, 2, 4, 5]

References

1.Profilin: at the crossroads of signal transduction and the actin cytoskeleton. Sohn RH, Goldschmidt-Clermont PJ. Bioessays 16, 465-72, (1994). View articlePMID: 7945274

2.Profilin, a weak CAP for actin and RAS. Goldschmidt-Clermont PJ, Janmey PA. Cell 66, 419-21, (1991). View articlePMID: 1651167

3.The three faces of profilin. Theriot JA, Mitchison TJ. Cell 75, 835-8, (1993). View articlePMID: 8252619

4.Signaling to the actin cytoskeleton. Schmidt A, Hall MN. Annu. Rev. Cell Dev. Biol. 14, 305-38, (1998). View articlePMID: 9891786

5.Actin dynamics: assembly and disassembly of actin networks. Wear MA, Schafer DA, Cooper JA. Curr. Biol. 10, R891-5, (2000). View articlePMID: 11137023

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