cd00195

UBCc

CDD entry
Member databaseCDD
CDD typedomain
Short nameUBCc
SetUBCc

Description

Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin protein ligase enzymes, E3. This pathway regulates many fundamental cellular processes. There are also other E2s which form thiol-ester linkages without the use of E3s as well as several UBC homologs (TSG101, Mms2, Croc-1 and similar proteins) which lack the active site cysteine essential for ubiquitination and appear to function in DNA repair pathways which were omitted from the scope of this CD.
[4, 2, 1, 3]

References

1.Three-dimensional structure of a ubiquitin-conjugating enzyme (E2). Cook WJ, Jeffrey LC, Sullivan ML, Vierstra RD. J. Biol. Chem. 267, 15116-21, (1992). View articlePMID: 1321826

2.Tertiary structures of class I ubiquitin-conjugating enzymes are highly conserved: crystal structure of yeast Ubc4. Cook WJ, Jeffrey LC, Xu Y, Chau V. Biochemistry 32, 13809-17, (1993). View articlePMID: 8268156

3.Themes and variations on ubiquitylation. Weissman AM. Nat Rev Mol Cell Biol 2, 169-78, (2001). PMID: 11265246

4.Crystal structure of a class I ubiquitin conjugating enzyme (Ubc7) from Saccharomyces cerevisiae at 2.9 angstroms resolution. Cook WJ, Martin PD, Edwards BF, Yamazaki RK, Chau V. Biochemistry 36, 1621-7, (1997). View articlePMID: 9048545

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