Member database | CDD |
CDD type | domain |
Short name | DHFR |
Set | DHFR |
Description
References
1.Eukaryotic dihydrofolate reductase. Blakley RL. Adv Enzymol Relat Areas Mol Biol 70, 23-102, (1995). PMID: 8638484
2.Structure-activity relationships of dihydrofolate reductase inhibitors. Bowden K, Harris NV, Watson CA. J Chemother 5, 377-88, (1993). PMID: 8195829
3.Evolution of the bacterial dihydrofolate reductase inhibitors. Periti P. J Antimicrob Chemother 36, 887-90, (1995). PMID: 8821588
4.Molecular aspects and mechanism of action of dihydrofolate reductase inhibitors. Hartman PG. J Chemother 5, 369-76, (1993). PMID: 8195828
5.Insights into antifolate resistance from malarial DHFR-TS structures. Yuvaniyama J, Chitnumsub P, Kamchonwongpaisan S, Vanichtanankul J, Sirawaraporn W, Taylor P, Walkinshaw MD, Yuthavong Y. Nat. Struct. Biol. 10, 357-65, (2003). View articlePMID: 12704428
6.Structure determination of tetrahydroquinazoline antifolates in complex with human and Pneumocystis carinii dihydrofolate reductase: correlations between enzyme selectivity and stereochemistry. Cody V, Luft JR, Pangborn W, Gangjee A, Queener SF. Acta Crystallogr. D Biol. Crystallogr. 60, 646-55, (2004). View articlePMID: 15039552
7.Phylogenetic classification of protozoa based on the structure of the linker domain in the bifunctional enzyme, dihydrofolate reductase-thymidylate synthase. O'Neil RH, Lilien RH, Donald BR, Stroud RM, Anderson AC. J. Biol. Chem. 278, 52980-7, (2003). View articlePMID: 14555647