cd00336

Ribosomal_L22

CDD entry
Member databaseCDD
CDD typedomain
Short nameRibosomal_L22
SetRibosomal_L22

Description

Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper folding and stabilizing the conformation of 23S rRNA. L22 is the largest protein contributor to the surface of the polypeptide exit channel, the tunnel through which the polypeptide product passes. L22 is also one of six proteins located at the putative translocon binding site on the exterior surface of the ribosome.
[7, 5, 4, 1, 2, 3, 6]

References

1.Crystal structure of the ribosome at 5.5 A resolution. Yusupov MM, Yusupova GZ, Baucom A, Lieberman K, Earnest TN, Cate JH, Noller HF. Science 292, 883-96, (2001). View articlePMID: 11283358

2.Mapping proteins of the 50S subunit from Escherichia coli ribosomes. Willumeit R, Diedrich G, Forthmann S, Beckmann J, May RP, Stuhrmann HB, Nierhaus KH. Biochim. Biophys. Acta 1520, 7-20, (2001). View articlePMID: 11470155

3.The structural basis of large ribosomal subunit function. Moore PB, Steitz TA. Annu. Rev. Biochem. 72, 813-50, (2003). View articlePMID: 14527328

4.L22 ribosomal protein and effect of its mutation on ribosome resistance to erythromycin. Davydova N, Streltsov V, Wilce M, Liljas A, Garber M. J. Mol. Biol. 322, 635-44, (2002). View articlePMID: 12225755

5.The structural basis of ribosome activity in peptide bond synthesis. Nissen P, Hansen J, Ban N, Moore PB, Steitz TA. Science 289, 920-30, (2000). View articlePMID: 10937990

6.The ribosome through the looking glass. Wilson DN, Nierhaus KH. Angew. Chem. Int. Ed. Engl. 42, 3464-86, (2003). View articlePMID: 12900959

7.The complete atomic structure of the large ribosomal subunit at 2.4 A resolution. Ban N, Nissen P, Hansen J, Moore PB, Steitz TA. Science 289, 905-20, (2000). View articlePMID: 10937989

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