cd00635

Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins

CDD entry
Member databaseCDD
CDD typedomain
Short namePLPDE_III_YBL036c_like
SetPLPDE_III

Description

This family contains mostly uncharacterized proteins, widely distributed among eukaryotes, bacteria and archaea, that bear similarity to the yeast hypothetical protein YBL036c, which is homologous to a Pseudomonas aeruginosa gene that is co-transcribed with a known proline biosynthetic gene. YBL036c is a single domain monomeric protein with a typical TIM barrel fold. It binds the PLP cofactor and has been shown to exhibit amino acid racemase activity. The YBL036c structure is similar to the N-terminal domain of the fold type III PLP-dependent enzymes, bacterial alanine racemase and eukaryotic ornithine decarboxylase, which are two-domain dimeric proteins. The lack of a second domain in YBL036c may explain limited D- to L-alanine racemase or non-specific racemase activity.
[1, 4, 2, 3]

References

1.Structure of a yeast hypothetical protein selected by a structural genomics approach. Eswaramoorthy S, Gerchman S, Graziano V, Kycia H, Studier FW, Swaminathan S. Acta Crystallogr. D Biol. Crystallogr. 59, 127-35, (2003). PMID: 12499548

2.A genomic overview of pyridoxal-phosphate-dependent enzymes. Percudani R, Peracchi A. EMBO Rep. 4, 850-4, (2003). View articlePMID: 12949584

3.A preliminary description of the crystal structure of gamma-glutamyltranspeptidase from E. coli K-12. Sakai H, Sakabe N, Sasaki K, Hashimoto W, Suzuki H, Tachi H, Kumagai H, Sakabe K. J Biochem 120, 26-8, (1996). PMID: 8864839

4.The manifold of vitamin B6 dependent enzymes. Schneider G, Kack H, Lindqvist Y. Structure 8, R1-6, (2000). View articlePMID: 10673430

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