cd00831

CHS_like

CDD entry
Member databaseCDD
CDD typedomain
Short nameCHS_like
Setcond_enzymes

Description

Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy, after the starter molecule is loaded onto the active site cysteine, a carboxylative condensation reation extends the polyketide chain. Plant-specific PKS are dimeric iterative PKSs, using coenzyme A esters to deliver substrate to the active site, but they differ in the choice of starter molecule and the number of condensation reactions.
[2, 4, 5, 1, 3]

References

1.Plant-like biosynthetic pathways in bacteria: from benzoic acid to chalcone. Moore BS, Hertweck C, Hopke JN, Izumikawa M, Kalaitzis JA, Nilsen G, O'Hare T, Piel J, Shipley PR, Xiang L, Austin MB, Noel JP. J. Nat. Prod. 65, 1956-62, (2002). View articlePMID: 12502351

2.Structure of chalcone synthase and the molecular basis of plant polyketide biosynthesis. Ferrer JL, Jez JM, Bowman ME, Dixon RA, Noel JP. Nat. Struct. Biol. 6, 775-84, (1999). View articlePMID: 10426957

3.The chalcone synthase superfamily of type III polyketide synthases. Austin MB, Noel JP. Nat Prod Rep 20, 79-110, (2003). PMID: 12636085

4.The Claisen condensation in biology. Heath RJ, Rock CO. Nat Prod Rep 19, 581-96, (2002). PMID: 12430724

5.Structural control of polyketide formation in plant-specific polyketide synthases. Jez JM, Austin MB, Ferrer J, Bowman ME, Schroder J, Noel JP. Chem. Biol. 7, 919-30, (2000). View articlePMID: 11137815

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