Member database | CDD |
CDD type | domain |
Short name | nicotinamidase |
Set | cysteine_hydrolases |
Description
Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is also called pyrazinamidase, because in converts the tuberculosis drug pyrazinamide (PZA) into its active form pyrazinoic acid (POA).
[2, 1]References
External Links
Representative structure
1im5: Crystal Structure of Pyrazinamidase of Pyrococcus horikoshii in Complex with Zinc