cd01116

P_permease

CDD entry
Member databaseCDD
CDD typedomain
Short nameP_permease
SetArsB_NhaD_permease

Description

Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the intraorganelle pH, together with the ATP-driven proton pump. It shows significant sequence similarity to the Na+/H+ antiporter NhaD from Vibrio parahaemolyticus. Both proteins belong to ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease contains 8-13 transmembrane domains.
[5, 3, 4, 1, 2]

References

1.Pink-eyed dilution protein modulates arsenic sensitivity and intracellular glutathione metabolism. Staleva L, Manga P, Orlow SJ. Mol Biol Cell 13, 4206-20, (2002). PMID: 12475946

2.A new Na+/H+ antiporter, NhaD, of Vibrio parahaemolyticus. Nozaki K, Kuroda T, Mizushima T, Tsuchiya T. Biochim. Biophys. Acta 1369, 213-20, (1998). View articlePMID: 9518619

3.Aberrant pH of melanosomes in pink-eyed dilution (p) mutant melanocytes. Puri N, Gardner JM, Brilliant MH. J Invest Dermatol 115, 607-13, (2000). PMID: 10998131

4.Organization and sequence of the human P gene and identification of a new family of transport proteins. Lee ST, Nicholls RD, Jong MT, Fukai K, Spritz RA. Genomics 26, 354-63, (1995). PMID: 7601462

5.The mouse p (pink-eyed dilution) and human P genes, oculocutaneous albinism type 2 (OCA2), and melanosomal pH. Brilliant MH. Pigment Cell Res. 14, 86-93, (2001). View articlePMID: 11310796

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