cd01127

TrwB/TraG/TraD/VirD4 family of bacterial conjugation proteins

CDD entry
Member databaseCDD
CDD typedomain
Short nameTrwB_TraG_TraD_VirD4
SetP-loop_NTPase

Description

The TraG/TraD/VirD4 family are bacterial conjugation proteins involved in type IV secretion (T4S) systems, versatile bacterial secretion systems mediating transport of protein and/or DNA. They are present in gram-negative and gram-positive bacteria, as well as archaea. They form hexameric rings and belong to the RecA-like NTPases superfamily, which also includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases.
[7, 4, 3, 6, 1, 5, 2]

References

1.Structure of TrwB, a gatekeeper in bacterial conjugation. Gomis-Ruth FX, Coll M. Int J Biochem Cell Biol 33, 839-43, (2001). PMID: 11461827

2.Bacterial type IV secretion: conjugation systems adapted to deliver effector molecules to host cells. Christie PJ, Vogel JP. Trends Microbiol. 8, 354-60, (2000). View articlePMID: 10920394

3.Bacterial conjugation: a two-step mechanism for DNA transport. Llosa M, Gomis-Ruth FX, Coll M, de la Cruz Fd F. Mol Microbiol 45, 1-8, (2002). PMID: 12100543

4.Conjugative plasmid transfer in gram-positive bacteria. Grohmann E, Muth G, Espinosa M. Microbiol Mol Biol Rev 67, 277-301, table of contents, (2003). PMID: 12794193

5.Conjugative plasmid protein TrwB, an integral membrane type IV secretion system coupling protein. Detailed structural features and mapping of the active site cleft. Gomis-Ruth FX, Moncalian G, de la Cruz F, Coll M. J. Biol. Chem. 277, 7556-66, (2002). View articlePMID: 11748238

6.Structure and role of coupling proteins in conjugal DNA transfer. Gomis-Ruth FX, de la Cruz F, Coll M. Res Microbiol 153, 199-204, (2002). PMID: 12066890

7.Phylogeny of genes for secretion NTPases: identification of the widespread tadA subfamily and development of a diagnostic key for gene classification. Planet PJ, Kachlany SC, DeSalle R, Figurski DH. Proc Natl Acad Sci U S A 98, 2503-8, (2001). PMID: 11226268

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