Member database | CDD |
CDD type | domain |
Short name | ATPase_flagellum-secretory_path_III |
Set | P-loop_NTPase |
Description
Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they both are proton-driven rotary molecular devices. However, the main function of the bacterial flagellar motor is to rotate the flagellar filament for cell motility. Intracellular pathogens such as Salmonella and Chlamydia also have proteins which are similar to the flagellar-specific ATPase, but function in the secretion of virulence-related proteins via the type III secretory pathway.
[7, 5, 1, 4, 3, 2, 6]References
1.Bacterial flagellar motor and H(+)/ATP synthase: two proton-driven rotary molecular devices with different functions. Walz D, Caplan SR. Bioelectrochemistry 55, 89-92, (2002). PMID: 11786348
2.Customized secretion chaperones in pathogenic bacteria. Wattiau P, Woestyn S, Cornelis GR. Mol Microbiol 20, 255-62, (1996). PMID: 8733225
3.The invasion-associated type-III protein secretion system in Salmonella--a review. Collazo CM, Galan JE. Gene 192, 51-9, (1997). PMID: 9224874
4.Molecular modeling of the bacterial outer membrane receptor energizer, ExbBD/TonB, based on homology with the flagellar motor, MotAB. Zhai YF, Heijne W, Saier MH Jr. Biochim. Biophys. Acta 1614, 201-10, (2003). View articlePMID: 12896813