Member database | CDD |
CDD type | domain |
Short name | PsaA |
Set | TroA-like |
Description
Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism. A typical TroA protein is comprised of two globular subdomains connected by a single helix and can bind the metal ion in the cleft between these domains. In addition, these proteins sometimes have a low complexity region containing a metal-binding histidine-rich motif (repetitive HDH sequence).
[2, 1, 3, 5, 4]References
1.Cell surface protein receptors in oral streptococci. Jenkinson HF. FEMS Microbiol Lett 121, 133-40, (1994). PMID: 7926661
2.A new family of high-affinity ABC manganese and zinc permeases. Claverys JP. Res. Microbiol. 152, 231-43, (2001). View articlePMID: 11421271
3.Identification of LpeA, a PsaA-like membrane protein that promotes cell entry by Listeria monocytogenes. Reglier-Poupet H, Pellegrini E, Charbit A, Berche P. Infect Immun 71, 474-82, (2003). PMID: 12496198
External Links
Representative structure
5jpd: Metal ABC transporter from Listeria monocytogenes with cadmium