cd01137

PsaA

CDD entry
Member databaseCDD
CDD typedomain
Short namePsaA
SetTroA-like

Description

Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism. A typical TroA protein is comprised of two globular subdomains connected by a single helix and can bind the metal ion in the cleft between these domains. In addition, these proteins sometimes have a low complexity region containing a metal-binding histidine-rich motif (repetitive HDH sequence).
[2, 1, 3, 5, 4]

References

1.Cell surface protein receptors in oral streptococci. Jenkinson HF. FEMS Microbiol Lett 121, 133-40, (1994). PMID: 7926661

2.A new family of high-affinity ABC manganese and zinc permeases. Claverys JP. Res. Microbiol. 152, 231-43, (2001). View articlePMID: 11421271

3.Identification of LpeA, a PsaA-like membrane protein that promotes cell entry by Listeria monocytogenes. Reglier-Poupet H, Pellegrini E, Charbit A, Berche P. Infect Immun 71, 474-82, (2003). PMID: 12496198

4.Preliminary X-ray crystallographic analysis of a soluble form of MntC, a periplasmic manganese-binding component of an ABC-type Mn transporter from Synechocystis sp. PCC 6803. Adir N, Rukhman V, Brumshtein B, Anati R. Acta Crystallogr D Biol Crystallogr 58, 1476-8, (2002). PMID: 12198307

5.Involvement of Lsp, a member of the LraI-lipoprotein family in Streptococcus pyogenes, in eukaryotic cell adhesion and internalization. Elsner A, Kreikemeyer B, Braun-Kiewnick A, Spellerberg B, Buttaro BA, Podbielski A. Infect Immun 70, 4859-69, (2002). PMID: 12183530

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