cd01168

adenosine_kinase

CDD entry
Member databaseCDD
CDD typedomain
Short nameadenosine_kinase
Setribokinase_pfkB_like

Description

Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular adenosine levels and the preservation of intracellular adenylate pools. Adenosine kinase is involved in the purine salvage pathway.
[2, 1, 5, 3, 4]

References

1.Nonnucleoside inhibitors of adenosine kinase. Gomtsyan A, Lee CH. Curr Pharm Des 10, 1093-103, (2004). PMID: 15078144

2.Therapeutic potential of adenosine kinase inhibitors. Kowaluk EA, Jarvis MF. Expert Opin Investig Drugs 9, 551-64, (2000). PMID: 11060695

3.Adenosine kinase inhibitors. Kowaluk EA, Bhagwat SS, Jarvis MF. Curr Pharm Des 4, 403-16, (1998). PMID: 10197052

4.Purine salvage pathways in myocardium. Manfredi JP, Holmes EW. Annu Rev Physiol 47, 691-705, (1985). PMID: 2986542

5.Cloning of human adenosine kinase cDNA: sequence similarity to microbial ribokinases and fructokinases. Spychala J, Datta NS, Takabayashi K, Datta M, Fox IH, Gribbin T, Mitchell BS. Proc. Natl. Acad. Sci. U.S.A. 93, 1232-7, (1996). View articlePMID: 8577746

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