Member database | CDD |
CDD type | domain |
Short name | IPT_RBP-Jkappa |
Set | IPT |
Description
IPT domain of the recombination signal Jkappa binding protein (RBP-Jkappa). RBP-J kappa, was initially considered to be involved in V(D)J recombination because of its DNA binding specificity and structural similarity to site-specific recombinases known as the integrase family. Further studies indicated that RBP-J kappa functions as a repressor of transcription, via destabilization of the general transcription factor IID and recruitment of histone deacetylase complexes.
[1, 2]References
1.HES and HERP families: multiple effectors of the Notch signaling pathway. Iso T, Kedes L, Hamamori Y. J. Cell. Physiol. 194, 237-55, (2003). View articlePMID: 12548545
2.SHARP is a novel component of the Notch/RBP-Jkappa signalling pathway. Oswald F, Kostezka U, Astrahantseff K, Bourteele S, Dillinger K, Zechner U, Ludwig L, Wilda M, Hameister H, Knochel W, Liptay S, Schmid RM. EMBO J. 21, 5417-26, (2002). View articlePMID: 12374742