cd01727

Like-Sm protein 8

CDD entry
Member databaseCDD
CDD typedomain
Short nameLSm8
SetSm_like

Description

The eukaryotic LSm proteins (LSm2-8 or LSm1-7) assemble into a hetero-heptameric ring around the 3'-terminus uridylation tag of the gamma-methyl triphosphate (gamma-m-P3) capped U6 snRNA. LSm2-8 form the core of the snRNP particle that, in turn, assembles with other components onto the pre-mRNA to form the spliceosome which is responsible for the excision of introns and the ligation of exons. LSm1-7 is involved in recognition of the 3' uridylation tag and recruitment of the decapping machinery. LSm657 is believed to be an assembly intermediate for both the LSm1-7 and LSm2-8 rings. Members of this family share a highly conserved Sm fold containing an N-terminal helix followed by a strongly bent five-stranded antiparallel beta-sheet.
[11, 6, 4, 8, 2, 3, 7, 1, 9, 5, 10]

References

1.LSm proteins form heptameric rings that bind to RNA via repeating motifs. Khusial P, Plaag R, Zieve GW. Trends Biochem. Sci. 30, 522-8, (2005). View articlePMID: 16051491

2.A Sm-like protein complex that participates in mRNA degradation. Bouveret E, Rigaut G, Shevchenko A, Wilm M, Seraphin B. EMBO J. 19, 1661-71, (2000). View articlePMID: 10747033

3.Yeast Sm-like proteins function in mRNA decapping and decay. Tharun S, He W, Mayes AE, Lennertz P, Beggs JD, Parker R. Nature 404, 515-8, (2000). View articlePMID: 10761922

4.The Sm domain is an ancient RNA-binding motif with oligo(U) specificity. Achsel T, Stark H, Luhrmann R. Proc. Natl. Acad. Sci. U.S.A. 98, 3685-9, (2001). View articlePMID: 11259661

5.3' Uridylation and the regulation of RNA function in the cytoplasm. Norbury CJ. Biochem. Soc. Trans. 38, 1150-3, (2010). View articlePMID: 20659020

6.Sm and Sm-like proteins assemble in two related complexes of deep evolutionary origin. Salgado-Garrido J, Bragado-Nilsson E, Kandels-Lewis S, Seraphin B. EMBO J. 18, 3451-62, (1999). View articlePMID: 10369684

7.Structure of the LSm657 complex: an assembly intermediate of the LSm1-7 and LSm2-8 rings. Mund M, Neu A, Ullmann J, Neu U, Sprangers R. J Mol Biol 414, 165-76, (2011). PMID: 22001694

8.Targeting an mRNA for decapping: displacement of translation factors and association of the Lsm1p-7p complex on deadenylated yeast mRNAs. Tharun S, Parker R. Mol. Cell 8, 1075-83, (2001). View articlePMID: 11741542

9.Lsm proteins and RNA processing. Beggs JD. Biochem. Soc. Trans. 33, 433-8, (2005). View articlePMID: 15916535

10.Roles of eukaryotic Lsm proteins in the regulation of mRNA function. Tharun S. Int Rev Cell Mol Biol 272, 149-89, (2009). View articlePMID: 19121818

11.Functions of Lsm proteins in mRNA degradation and splicing. He W, Parker R. Curr. Opin. Cell Biol. 12, 346-50, (2000). View articlePMID: 10801455

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