cd01740

Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase

CDD entry
Member databaseCDD
CDD typedomain
Short nameGATase1_FGAR_AT
SetGAT_1

Description

Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase (FGAR-AT). FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP, Pi, and glutamate in the fourth step of the purine biosynthetic pathway. FGAR-AT is a glutamine amidotransferase. Glutamine amidotransferase activity catalyses the transfer of ammonia from the amide side chain of glutamine to an acceptor substrate. FGAR-AT belongs to the triad family of amidotransferases having a conserved Cys-His-Glu catalytic triad in the glutaminase active site
[4, 1, 2, 3]

References

1.Enzymes with molecular tunnels. Raushel FM, Thoden JB, Holden HM. Acc. Chem. Res. 36, 539-48, (2003). View articlePMID: 12859215

2.The amidotransferase family of enzymes: molecular machines for the production and delivery of ammonia. Raushel FM, Thoden JB, Holden HM. Biochemistry 38, 7891-9, (1999). View articlePMID: 10387030

3.Structural role for a conserved region in the CTP synthetase glutamine amide transfer domain. Weng ML, Zalkin H. J. Bacteriol. 169, 3023-8, (1987). View articlePMID: 3298209

4.Domain organization of Salmonella typhimurium formylglycinamide ribonucleotide amidotransferase revealed by X-ray crystallography. Anand R, Hoskins AA, Stubbe J, Ealick SE. Biochemistry 43, 10328-42, (2004). View articlePMID: 15301531

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