cd01894

EngA1 GTPase contains the first domain of EngA

CDD entry
Member databaseCDD
CDD typedomain
Short nameEngA1
SetP-loop_NTPase

Description

This EngA1 subfamily CD represents the first GTPase domain of EngA and its orthologs, which are composed of two adjacent GTPase domains. Since the sequences of the two domains are more similar to each other than to other GTPases, it is likely that an ancient gene duplication, rather than a fusion of evolutionarily distinct GTPases, gave rise to this family. Although the exact function of these proteins has not been elucidated, studies have revealed that the E. coli EngA homolog, Der, and Neisseria gonorrhoeae EngA are essential for cell viability. A recent report suggests that E. coli Der functions in ribosome assembly and stability.
[3, 7, 8, 6, 4, 2, 5, 9, 1]

References

1.Six GTP-binding proteins of the Era/Obg family are essential for cell growth in Bacillus subtilis. Morimoto T, Loh PC, Hirai T, Asai K, Kobayashi K, Moriya S, Ogasawara N. Microbiology (Reading, Engl.) 148, 3539-52, (2002). PMID: 12427945

2.Function of the universally conserved bacterial GTPases. Caldon CE, March PE. Curr. Opin. Microbiol. 6, 135-9, (2003). View articlePMID: 12732302

3.Conserved P-loop GTPases of unknown function in bacteria: an emerging and vital ensemble in bacterial physiology. Brown ED. Biochem. Cell Biol. 83, 738-46, (2005). View articlePMID: 16333325

4.Survey for g-proteins in the prokaryotic genomes: prediction of functional roles based on classification. Pandit SB, Srinivasan N. Proteins 52, 585-97, (2003). View articlePMID: 12910458

5.Evolution of a molecular switch: universal bacterial GTPases regulate ribosome function. Caldon CE, Yoong P, March PE. Mol. Microbiol. 41, 289-97, (2001). View articlePMID: 11489118

6.Classification and evolution of P-loop GTPases and related ATPases. Leipe DD, Wolf YI, Koonin EV, Aravind L. J. Mol. Biol. 317, 41-72, (2002). View articlePMID: 11916378

7.Cloning and characterization of engA, a GTP-binding protein from Mycobacterium tuberculosis H(37)Rv. Meena LS, Rajni . Biologicals 39, 94-9, (2011). PMID: 21330151

8.The extracellular β-1,3-endoglucanase EngA is involved in autolysis of Aspergillus nidulans. Szilagyi M, Kwon NJ, Dorogi C, Pocsi I, Yu JH, Emri T. J Appl Microbiol 109, 1498-508, (2010). PMID: 20602653

9.Comparative genomics of prokaryotic GTP-binding proteins (the Era, Obg, EngA, ThdF (TrmE), YchF and YihA families) and their relationship to eukaryotic GTP-binding proteins (the DRG, ARF, RAB, RAN, RAS and RHO families). Mittenhuber G. J. Mol. Microbiol. Biotechnol. 3, 21-35, (2001). PMID: 11200227

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