Member database | CDD |
CDD type | domain |
Short name | TPP_E1_EcPDC_like |
Set | TPP_enzymes |
Description
References
1.Inhibition of the Escherichia coli pyruvate dehydrogenase complex E1 subunit and its tyrosine 177 variants by thiamin 2-thiazolone and thiamin 2-thiothiazolone diphosphates. Evidence for reversible tight-binding inhibition. Nemeria N, Yan Y, Zhang Z, Brown AM, Arjunan P, Furey W, Guest JR, Jordan F. J Biol Chem 276, 45969-78, (2001). PMID: 11583990
2.A mutant pyruvate dehydrogenase E1 subunit allows survival of Escherichia coli strains defective in 1-deoxy-D-xylulose 5-phosphate synthase. Sauret-Gueto S, Uros EM, Ibanez E, Boronat A, Rodriguez-Concepcion M. FEBS Lett 580, 736-40, (2006). PMID: 16414046
3.Structure of the pyruvate dehydrogenase multienzyme complex E1 component from Escherichia coli at 1.85 A resolution. Arjunan P, Nemeria N, Brunskill A, Chandrasekhar K, Sax M, Yan Y, Jordan F, Guest JR, Furey W. Biochemistry 41, 5213-21, (2002). View articlePMID: 11955070
4.Structural determinants of enzyme binding affinity: the E1 component of pyruvate dehydrogenase from Escherichia coli in complex with the inhibitor thiamin thiazolone diphosphate. Arjunan P, Chandrasekhar K, Sax M, Brunskill A, Nemeria N, Jordan F, Furey W. Biochemistry 43, 2405-11, (2004). View articlePMID: 14992577
5.Amino-terminal residues 1-45 of the Escherichia coli pyruvate dehydrogenase complex E1 subunit interact with the E2 subunit and are required for activity of the complex but not for reductive acetylation of the E2 subunit. Park YH, Wei W, Zhou L, Nemeria N, Jordan F. Biochemistry 43, 14037-46, (2004). PMID: 15518552